Volume 2.47 | Nov 29

Hematopoiesis News 2.47, November 29, 2011
Hematopoiesis News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Here, scientists demonstrate that TGF-β type II receptor-deficient hematopoietic stem cells (HSCs) show low-level Smad activation and impaired long-term repopulating activity, underlining the critical role of TGF-β/Smad signaling in HSC maintenance. [Cell] Abstract


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PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH

Rac Signaling in Osteoblastic Cells Is Required for Normal Bone Development but Is Dispensable for Hematopoietic Development
Data have implications for therapeutic strategies to target Rac signaling in hematopoietic stem cell (HSC) mobilization and the treatment of leukemia, and provide clarification to the evolving concepts of HSC-hematopoietic microenvironment interactions. [Blood] Abstract


Genetic Screen Identifies MicroRNA Cluster 99b/let-7e/125a as a Regulator of Primitive Hematopoietic Cells
Researchers performed a genetic screen for microRNAs that are differentially expressed between LSK, LSK+, erythroid and myeloid cells isolated from C57BL/6 and DBA/2 mice. [Blood] Abstract

The Canonical Wnt Pathway Shapes Niches Supportive for Hematopoietic Stem/Progenitor Cells
Here, scientists have investigated Wnt signaling and assessed its influence on human and murine hematopoiesis. [Blood] Abstract


Blockade of Prostaglandin E2 Signaling through EP1 and EP3 Receptors Attenuates Flt3L-Dependent Dendritic Cell Development from Hematopoietic Progenitor Cells
Investigators show that prostaglandin E2 is required for optimal Flt3-ligand-mediated dendritic cell (DC) development and regulates expression of the Flt3 receptor on DC-committed progenitor cells. [Blood] Abstract


Low BCR-ABL Expression Levels in Hematopoietic Precursor Cells Enable Persistence of Chronic Myeloid Leukemia Under Imatinib
Scientists have shown that the number of BCR-ABL positive precursors decreases significantly in all bone marrow compartments during major molecular remission. [Blood] Abstract


Human Bone Marrow Hematopoietic Stem Cells Are Increased in Frequency and Myeloid-Biased with Age
To elucidate the properties of an aged human hematopoietic system that may predispose to age-associated hematopoietic dysfunction, researchers evaluated immunophenotypic hematopoietic stem cells and other hematopoietic progenitor populations from healthy, hematologically normal young and elderly human bone marrow samples. [Proc Natl Acad Sci USA] Abstract | Press Release

CLINICAL RESEARCH

Hematopoietic Stem Cell Transplantation in T-Prolymphocytic Leukemia: A Retrospective Study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium
The purpose of the present study was to analyze the outcome of transplants for T-prolymphocytic leukemia registered with the European Group for Blood and Marrow Transplantation database and the Royal Marsden Consortium. [Leukemia] Abstract


Landscape of TET2 Mutations in Acute Myeloid Leukemia
Scientists investigated ten–eleven translocation 2 (TET2) mutations in acute myeloid leukemia, their correlation with other gene mutations and prognostic value. [Leukemia] Abstract

Treatment with High-Dose Simvastatin Inhibits Geranylgeranylation in AML Blast Cells in a Subset of AML Patients
Data demonstrates that simvastatin treatment results in chemosensitization and inhibition of geranylgeranylation in acute myeloid leukemia (AML) cells of a subset of patients. [Exp Hematol] Abstract


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INDUSTRY NEWS
Micromet Initiates Global Phase II Trial of Blinatumomab in Adult Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia
Micromet, Inc. announced that it has initiated a phase II trial of its lead product candidate blinatumomab (MT103) in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. [Micromet, Inc.] Press Release


Sanford Consortium Opens New “Collaboratory”: First of Its Kind Stem Cell Science Facility Will Harness Intellectual Capital of Five World-Class Research Institutions
The Sanford Consortium for Regenerative Medicine opened a new collaborative research building, formally launching California’s newest facility dedicated to stem cell science. [Sanford Consortium for Regenerative Medicine] Press Release
POLICY NEWS
Cancer Drugs Recall
The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended a recall of three drugs used in cancer therapy following an inspection of a US manufacturing site that highlighted several quality assurance problems in the sterilization process. [Medicines and Healthcare products Regulatory Agency, European Union] Press Release


Direct Recall Classification Program (Blood and Plasma) [Center for Biologics Evaluation and Research, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW Keystone Symposia: The Life of a Stem Cell: From Birth to Death
March 11-16, 2012
Olympic Valley, United States

Visit our events page 
to see a complete list of events in the hematopoietic community
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Marie Curie Experienced Researcher (Alexander Fleming Biomedical Sciences Research Center)

Postdoctoral Position – Center for Human Genetics (VIB Research Institute)

Postgraduate Students (Masaryk University)

Research Postdoctoral Position (National Taiwan University)

Postdoctoral Fellow – Hematopoietic Stem Cells (City of Hope)

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