Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Impact of Clonal Hematopoiesis of Indeterminate Potential on Hepatocellular Carcinoma in Individuals with Steatotic Liver Disease

[Hepatology] Investigators examined whether clonal hematopoiesis of indeterminate potentia was associated with HCC development in patients with steatotic liver disease.

Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

[Journal Of Clinical Oncology] Adults with FLT3-ITD AML in first remission underwent hematopoietic cell transplantation (HCT) and were randomly assigned to placebo or 120mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival.

STAT3 Protects Hematopoietic Stem Cells by Preventing Activation of a Deleterious Autocrine Type-I Interferon Response

[Leukemia] Scientists developed mixed bone marrow chimeric mice with inducible Stat3 deletion in 20% of the hematopoietic compartment to avoid systemic inflammation. Stat3-deficient HSPCs were significantly impaired in reconstitution ability following primary or secondary bone marrow transplantation, indicating hematopoietic stem cell defects.

FDA Approves Inotuzumab Ozogamicin for Pediatric CD22+ B-Cell Precursor Acute Lymphoblastic Leukemia

[OncLive] The FDA has approved inotuzumab ozogamicin for the treatment of pediatric patients aged one year and older with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia.

Osteomacs Promote Maintenance of Murine Hematopoiesis Through Megakaryocyte-Induced Upregulation of Embigin and CD166

[Stem Cell Reports] The authors characterized osteomacs (OMs) and identify megakaryocyte-induced mediators that augment the role of OM in the niche. Single-cell mRNA-seq, mass spectrometry, and CyTOF examination of megakaryocyte-stimulated OM suggested that upregulation of CD166 and Embigin on OM augment their hematopoiesis maintenance function.

A Mitochondrial NADPH-Cholesterol Axis Regulates Extracellular Vesicle Biogenesis to Support Hematopoietic Stem Cell Fate

[Cell Stem Cell] Investigators showed that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, which are required for proper HSC cell fate and homeostasis.

Joint Analysis of Mutational and Transcriptional Landscapes in Human Cancer Reveals Key Perturbations During Cancer Evolution

[Genome Biology] Scientists analyzed cancer evolution and clonal selection by jointly considering mutational and transcriptomic profiles of single cells acquired from tumor biopsies from 49 lung cancer samples and 51 samples with chronic myeloid leukemia.

In Vivo Ablation of NFκB Cascade Effectors Alleviates Disease Burden in Myeloproliferative Neoplasms

[Blood] Researchers systematically ablated NFκB signaling effectors to identify core dependencies using a series of primary samples and syngeneic and patient-derived xenograft mouse models.

Autologous Gene Therapy for Hemoglobinopathies: From Bench to Patient’s Bedside

[Molecular Therapy] The authors review the mechanisms of action of these various gene addition and gene editing approaches and describe the status of clinical trials designed to evaluate the potentially for these approaches to provide one-time functional cures to patients with transfusion-dependent β-thalassemia and sickle cell disease.

Differentiation Route Determines the Functional Outputs of Adult Megakaryopoiesis

[Immunity] Scientists developed fate-mapping systems to distinguish the two routes, comparing their quantitative and functional outputs. We found that megakaryocytes were produced through the two routes with comparable kinetics and quantity under homeostasis.

Epigenetic Control Over Cell-Intrinsic Immune Response Antagonizes Self-Renewal in Acute Myeloid Leukemia

[Blood] Researchers unveiled the histone demethylase PHF8 as a direct initiator and regulator of cell-intrinsic immune response in AML. Site-specific phosphorylation of PHF8 orchestrated epigenetic changes that upregulate cytosolic RNA sensors, particularly the TRIM25-RIG-I-IFIT5 axis, thereby triggering the cellular IFN-I response-differentiation-apoptosis network.

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia

[Leukemia] Scientists showed that max-gene-associated regulated multiple pro-proliferative pathways in hematopoietic cells and cooperated with the RUNX1::RUNX1T1 fusion oncoprotein to enhance leukemogenesis.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

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