Volume 2.18 | May 10

Hematopoiesis News 2.18, May 10, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Link Between Ribosome Maturation and Cancer
A team of researchers has identified the conserved mechanism that underlies a critical step in the maturation of ribosomes and showed that this step is defective in an inherited form of bone marrow failure that is associated with significant leukemia predisposition (Shwachman-Diamond syndrome). [Press release from the Medical Research Council Laboratory of Molecular Biology discussing online prepublication in Genes & Development]

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SCIENCE NEWS

Acetaminophen Tied to Blood Cancers
New research shows chronic users of acetaminophen are at slightly increased risk for blood cancers. [Press release from Reuters discussing online prepublication in the Journal of Clinical Oncology]

Researchers Develop Technique for Measuring Stressed Molecules in Cells
Biophysicists have helped develop a new technique for studying how proteins respond to physical stress and have applied it to better understand the stability-granting structures in normal and mutated red blood cells. [Press release from the University of Pennsylvania discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
Scientists used single-cell “mass cytometry” to examine healthy human bone marrow, measuring 34 parameters simultaneously in single cells (binding of 31 antibodies, viability, DNA content, and relative cell size). [Science]

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging
Using a model carrying a proofreading-defective mitochondrial DNA polymerase, researchers demonstrate hematopoietic defects reminiscent of premature HSC aging, including anemia, lymphopenia, and myeloid lineage skewing. [Cell Stem Cell]

Uncoupling of GTP Hydrolysis from eIF6 Release on the Ribosome Causes Shwachman-Diamond Syndrome
By isolating late cytoplasmic 60S ribosomal subunits from Sbds-deleted mice, investigators show that Shwachman-Bodian-Diamond syndrome (SBDS) and the GTPase elongation factor-like 1 (EFL1) directly catalyze eukaryotic initiation factor 6 (eIF6) removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFL1 but not phosphorylation of eIF6 Ser 235. [Genes Dev]

Crebbp Haploinsufficiency in Mice Alters the Bone Marrow Microenvironment Leading to Loss of Stem Cells and Excessive Myelopoiesis
Scientists describe that CREB binding protein (CREBBP) plays an equally pivotal role in microenvironment-mediated regulation of hematopoiesis. [Blood]

Cysteine Shotgun–Mass Spectrometry (CS-MS) Reveals Dynamic Sequence of Protein Structure Changes within Mutant and Stressed Cells
Cysteine shotgun labeling with fluorophores is analyzed with mass spectrometry of the spectrin–actin membrane skeleton in sheared red blood cell ghosts from normal and diseased mice. [Proc Natl Acad Sci U S A]

A Novel Role of the CX3CR1/CX3CL1 System in the Cross-Talk Between Chronic Lymphocytic Leukemia Cells and Tumor Microenvironment
Researchers investigated whether the CX3CR1/CX3CL1 axis is involved in the interaction of chronic lymphocytic leukemia with their microenvironment. [Leukemia]

Regulation of Erythroid Differentiation by miR-376a and Its Targets
Investigators report that miR-376a participates in the regulation of the early stages of human erythropoiesis by targeting cyclin-dependent kinase 2 and Argonaute 2. [Cell Res]

CLINICAL RESEARCH

Long-Term Use of Acetaminophen, Aspirin, and Other Nonsteroidal Anti-Inflammatory Drugs and Risk of Hematologic Malignancies: Results From the Prospective Vitamins and Lifestyle (VITAL) Study
Among previous studies examining the associations of over-the-counter analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs) and incident hematologic malignancies, results were inconsistent for NSAIDs but suggested an increased risk with acetaminophen (paracetamol). Herein, scientists used a large prospective cohort study to examine these associations. [J Clin Oncol]

A Phase II Study of Lenalidomide Monotherapy in Patients with Deletion 5q Acute Myeloid Leukemia: SWOG Study S0605
This Phase II study explores the safety and efficacy of single agent lenalidomide in previously untreated older AML patients with chromosome 5q deletion who declined standard chemotherapy. [Blood]

HIV-Associated Hodgkin Lymphoma During the First Months on Combination Antiretroviral Therapy
Researchers evaluated Hodgkin lymphoma risk by use of combination antiretroviral therapies, especially during the first months of treatment. [Blood]

Prophylactic Transfer of BCR-ABL–, PR1-, and WT1-Reactive Donor T Cells After T-Cell–Depleted Allogeneic Hematopoietic Cell Transplantation in Patients with Chronic Myeloid Leukemia
Scientists investigated the effects of prophylactic infusion of in vitro-generated donor T cells reactive against peptides derived from chronic myeloid leukemia-associated antigens. [Blood]

Prognostic Impact of FLT3-ITD Load in NPM1 Mutated Acute Myeloid Leukemia
To clarify whether FLT3-ITD load as expressed as FLT3-ITD/ wildtype (wt) ratio is also relevant in patients with NPM1 mutated AML, investigators assessed the FLT3-ITD mutation status and FLT3-ITD/wt ratio by fragment analysis in 638 NPM1mut AML (339 females; 299 males; 17.8–88.0 years), and analyzed its prognostic relevance in 355 patients. [Leukemia]

Allogeneic Hematopoietic SCT for Alpha-Mannosidosis: An Analysis of 17 Patients
This retrospective multi institutional analysis describes 17 patients that were diagnosed at a median of 2.5 (1.1–23) years and underwent hematopoietic SCT at a median of 3.6 (1.3–23.1) years. [Bone Marrow Transplant]

INDUSTRY NEWS

Grifols and Talecris Biotherapeutics Announce the Signing of a Consent Agreement with FTC Staff
Grifols, S.A. and Talecris Biotherapeutics Holdings Corp. announced they have signed a Consent Agreement with the staff of the Bureau of Competition of the U.S. Federal Trade Commission (FTC) that outlines the conditions necessary for Grifols’ acquisition of Talecris to proceed. [Talecris Biotherapeutics Holdings Corp Press Release]


Lorus Therapeutics Announces Allowance of United States Patent for Cancer Drug LOR-2040 in the Treatment of Acute Myeloid Leukemia
Lorus Therapeutics Inc. announced that the United States Patent and Trademark Office has allowed a new patent for the Company’s lead clinical stage cancer drug LOR-2040 in the treatment of Acute Myeloid Leukemia. [Lorus Therapeutics Inc. Press Release]

Ohio State Leukemia Expert To Join National Academy
Dr. Clara D. Bloomfield is among 212 leaders in the sciences, social sciences, humanities, the arts, business and public affairs who are members of the 2011 class of the American Academy of Arts and Sciences. [The Ohio State University Medical Center Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Stem Cells in Development and Disease 2011
September 11-14, 2011
Berlin, Germany

NEW Stem Cells USA & Regenerative Medicine Congress
September 12-15, 2011
Boston, United States

Visit our events page to see a complete list of events in the hematopoietic community

JOB OPPORTUNITIES
Post Doctoral Fellow (MedImmune)
 
Research Assistant (King’s College London)

Laboratory Project Scientist (University of California, San Diego)

Postdoctoral Fellow (Indiana University) 

Research Associate (University of Massachusetts Medical School)

Early Stage Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Medical Center Groningen) 

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