Volume 2.14 | Apr 12

Hematopoiesis News 2.14, April 12, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
Results demonstrated an essential function of Hif1α-Notch interaction in maintaining cancer stem cells (CSCs) and provided an effective approach to target CSCs for therapy of hematological malignancies. [Cell Stem Cell]

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SCIENCE NEWS
New Drug Shows Potential for Treatment-Resistant Leukemia 
Researchers found that a novel drug shows promise for treating leukemia patients who have few other options because their disease has developed resistance to standard treatment. [Press release from ScienceDaily discussing online prepublication in Cancer Cell

Transcriptional Silencing of ASS1 Suggests the Potential Use of ADI-PEG 20 to Treat AML, Glioblastoma and Bladder Cancer
Polaris Group announced that data from preclinical studies suggest ADI-PEG 20 may be effective in treating acute myeloid leukemia (AML), glioblastoma multiforme and bladder cancer. [Press release from Polaris Group discussing data presented at the 102nd Annual Meeting of the American Association for Cancer Research]

 
 
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
Using structure-based drug design, scientists developed compounds that bind to residues (Arg386/Glu282) ABL1 uses to switch between inactive and active conformations. [Cancer Cell]

Adult Hematopoiesis Is Regulated by TIF1γ, a Repressor of TAL1 and PU.1 Transcriptional Activity
Researchers showed that deletion of TIF1γ in adult hematopoiesis is compatible with life and long-term maintenance of essential blood cell lineages. [Cell Stem Cell]

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models
Investigators described preclinical analyses of the therapeutic potential of dimethyl-prostaglandin E2 treatment by using human and nonhuman primate hematopoietic stem cells. [Cell Stem Cell]

A Novel TNFR1-Triggered Apoptosis Pathway Mediated by Class IA PI3Ks in Neutrophils
Scientists reported surprising differences in the molecular mechanisms used for caspase activation between FAS/CD95- and TNF receptor 1 (TNFR1)-stimulated neutrophils. [Blood]

SMAD4 Binds HOXA9 in the Cytoplasm and Protects Primitive Hematopoietic Cells Against Nuclear Activation by HOXA9 and Leukemia Transformation
Investigators studied leukemic stem cells in a Smad4-/- mouse model of acute myelogenous leukemia induced either by the HOXA9 gene or by the fusion oncogene NUP98-HOXA9. [Blood]

Protein Disulfide Isomerase Blocks CEBPA Translation and Is Upregulated During the Unfolded Protein Response in Acute Myeloid Leukemia
Scientists screened for additional CEBPA mRNA binding proteins and they identified protein disulfide isomerase, an endoplasmic reticulum resident protein, to bind to the CEBPA mRNA stem loop region. [Blood]

TNF-α–Dependent Loss of IKKβ-Deficient Myeloid Progenitors Triggers a Cytokine Loop Culminating in Granulocytosis
Investigators identified a regulatory cytokine loop that causes neutrophilia in Ikkβ−deficient mice. [Proc Natl Acad Sci USA]

HDAC Inhibitors Potentiate the Activity of the Bcr/Abl Kinase Inhibitor KW-2449 in Imatinib-Sensitive and -Resistant Bcr/Abl+ Leukemia Cells In Vitro and In Vivo
The purpose of this study was to determine whether HDAC inhibitors such as vorinostat or entinostat (SNDX-275) could increase the lethality of the dual Bcr/Abl-aurora kinase inhibitor KW-2449 in various Bcr/Abl+ human leukemia cells, including those resistant to imatinib mesylate. [Clin Cancer Res]

CLINICAL RESEARCH

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
To identify oncogenic pathways in T cell acute lymphoblastic leukemia, scientists combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip method. [Cancer Cell]

Mutations in ANKRD26 Are Responsible for a Frequent Form of Inherited Thrombocytopenia: Analysis of 78 Patients from 21 Families
Researchers recently identified mutations in the 5’UTR region of ANKRD26 gene in 9 thrombocytopenia 2 families. Here they report on 12 additional pedigrees with ANKRD26 mutations, 6 of which are new. [Blood]

The Addition of Arsenic Trioxide to Low-Dose Ara-C in Older Patients with Acute Myeloid Leukemia Does Not Improve Outcome
Investigators report a randomized trial of low-dose Ara-C (LDAC) versus LDAC and arsenic trioxide. [Leukemia]
INDUSTRY NEWS
HemaCare Names Dr. Scott Burger Scientific Advisory Board Chair
HemaCare Corporation named Scott R. Burger, MD as the Chairperson of its Scientific Advisory Board. [HemaCare Corporation Press Release]

American Society of Hematology Partners with Agrupación Mexicana para el Estudio de la Hematología and National Cancer Institute to Improve Diagnosis of Acute Myeloid Leukemia in Mexico
A workshop served as the launch of a unique project that united the American Society of Hematology, the Agrupación Mexicana para el Estudio de la Hematología, and the National Cancer Institute in pursuit of a common goal: improving the care of patients with acute myeloid leukemia. [American Society of Hematology Press Release]
POLICY NEWS
Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2011-8146) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW American Association for Cancer Research: Metabolism and Cancer
October 16-19, 2011
Baltimore, United States

NEW 10th Annual American Association for Cancer Research Conference on Frontiers in Cancer Prevention Research
October 22-25, 2011
Boston, United States

Visit our events page 
to see a complete list of events in the hematopoietic community
JOB OPPORTUNITIES
Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Research Associate (University of Massachusetts Medical School)

Post-Doctoral Research Fellows – Transcriptional Control in Hematopoietic Stem Cells and Leukemia (Institut de Recherches Cliniques de Montréal) 

Research Technologist – Pharmaceutical Sciences (St. Jude Children’s Research Hospital)

Postdoctoral Fellow or Research Associate (City University of New York)

Postdoctoral Fellow (New Jersey Medical School)


Early Stage Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Medical Center Groningen) 

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