Volume 2.06 | Feb 15

Hematopoiesis News 2.06, February 15, 2011.
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
 
TOP STORY
Development of IL-22 Producing NK Lineage Cells from Umbilical Cord Blood Hematopoietic Stem Cells in the Absence of Secondary Lymphoid Tissue
IL-22 producing NK cells can be generated in the absence of secondary lymphoid tissues. Hematopoietic stem cell-derived NK22 cells will be valuable in understanding this rare NK subset and create the opportunity for human translational clinical trials. [Blood]

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SCIENCE NEWS
Childhood Cancer Treatment Found to Pose Similar Risk for Breast Cancer as BRCA Mutations
New data reveals that women treated with radiation to the chest for childhood cancer have a high risk of developing breast cancer similar to that of women with BRCA1/2 mutations. [Press release from Memorial Sloan-Kettering Cancer Center discussing research presented at the American Society of Clinical Oncology (ASCO) Annual 2012 Meeting, Chicago] Press Release
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Targeted Deletion of the Mouse Mitoferrin1 Gene: From Anemia to Protoporphyria
Results show that the activity of mitoferrin1 is required to manage an increase in heme synthesis. The data also show that alterations in heme synthesis within hepatocytes can lead to protophorphyria and hepatotoxicity. [Blood]

KDM2b/JHDM1b, A Histone H3 Lysine 36 Dimethyl-Specific Demethylase, Is Required for Initiation and Maintenance of Acute Myeloid Leukemia
Investigators demonstrate that ectopic expression of Kdm2b/Jhdm1b is sufficient to transform hematopoietic progenitors. [Blood]

Integrated Genome-Wide Chromatin Occupancy and Expression Analyses Identify Key Myeloid Pro-Differentiation Transcription Factors Repressed by Myb
To gain insight into the mechanisms by which the Myb transcription factor controls normal hematopoiesis and particularly, how it contributes to leukemogenesis, researchers mapped the genome-wide occupancy of Myb by chromatin immunoprecipitation followed by massively parallel sequencing in ERMYB myeloid progenitor cells. [Nucleic Acid Res]

Coordinated Involvement of Cathepsins S, D and Cystatin C in the Commitment of Hematopoietic Stem Cells to Dendritic Cells
The identity of biochemical players which underpin the commitment of CD34+hematopoietic stem cells to immunogenic or tolerogenic dendritic cells is largely unknown. To explore this issue, scientists employed a previously established cell-based system amenable to shift dendritic cell differentiation from the immunogenic into the tolerogenic pathway upon supplementation with a conventional cytokine cocktail containing thrombopoietin and IL-16. [Int J Biochem Cell Biol]

Adaptor Protein Lnk Binds to PDGF Receptor and Inhibits PDGF-Dependent Signaling
Investigators show that Lnk binds to platelet-derived growth factor (PDGF) receptor after exposure of cells to PDGF. Furthermore, Lnk can bind the FIP1L1-PDGFR alpha fusion protein. [Exp Hematol]

Induction of Apoptosis by Cordycepin via Reactive Oxygen Species Generation in Human Leukemia Cells
Results support a mechanism whereby cordycepin induces apoptosis of human leukemia cells through a signaling cascade involving a reactive oxygen species-mediated caspase pathway. [Toxicol In Vitro]

DIGE-Based Proteomic Analysis Identifies Nucleophosmin/B23 and Nucleolin C23 as Over-Expressed Proteins in Relapsed/Refractory Acute Leukemia
To investigate novel protein changes involved in resistance, protein expression profiles between leukemia cell line HL-60 and adriamycin-resistant HL-60 were compared based on a proteomic approach-2D-differential in gel electrophoresis (DIGE) followed by MALDI-TOF/MS. [Leuk Res]

CLINICAL RESEARCH

Ancestry and Pharmacogenomics of Relapse in Acute Lymphoblastic Leukemia
Interrogating genome-wide germline SNP genotypes in an unselected large cohort of children with acute lymphoblastic leukemia, researchers observed that the component of genomic variation that co-segregated with Native American ancestry was associated with risk of relapse (P = 0.0029) even after adjusting for known prognostic factors (P = 0.017). [Nat Genet]

Absence of Class II-Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4+ T Cells
Investigators evaluated the functional significance of class II-associated invariant chain peptide expression on leukemic blasts of acute myeloid leukemia patients. [Cancer Res]

Comparative Proteomic Analysis of Blood Eosinophils Reveals Redox Signaling Modifications in Patients with FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia
To define more precisely intrinsic molecular events associated with FIP1L1-PDGFRA (F/P) gene, scientists performed a proteomic analysis comparing F/P+ eosinophils and eosinophils from healthy donors. [J Proteome Res]

INDUSTRY NEWS
Vical Reports 2010 Financial Results and Progress in Key Development Programs
Vical Incorporated reported financial results for the year ended December 31, 2010. Vical had cash and investments of approximately $61 million at year-end 2010. The company received approximately $37 million of net proceeds from the sale of equity securities during 2010. [Vical Incorporated Press Release]

UCSF Stem Cell Building Opens, A Milestone for Pioneering Program
The University of California, San Francisco (UCSF) celebrates the official opening of the Ray and Dagmar Dolby Regeneration Medicine Building, a testament to the power of perseverance in the stem cell field. [University of California, San Francisco Press Release]

Hinxton Group Warns Against Stifling Effect of Widespread Patenting in Stem Cell Field
A team of scholars urges the scientific community to act collectively to stem the negative effects of patenting and privatizing of stem cell lines, data and pioneering technologies. This means grappling with the ambiguity of several fundamental distinctions typically made in ethics, law, and common practice, the experts insist. [Johns Hopkins Berman Institute of Bioethics Press Release]

Lilly CEO Says Industry, Public Policy Must Pave Way For Innovation
A new approach to research, along with public policies that support medical innovation, will help biopharmaceutical companies address stubborn diseases with potentially devastating personal and financial consequences, such as cancer and Alzheimer’s disease, according to John Lechleiter, Ph.D., chairman, president and CEO of Eli Lilly and Company. [Eli Lilly and Company Press Release]
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

Visit our events page to see a complete list of events in the hematopoietic community.

JOB OPPORTUNITIES

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Field Applications Specialist – Cell Therapy (Medical) (Pall Corporation)

Postdoctoral Position – Germline Stem Cells (R. L. Brinster, School of Veterinary Medicine, University of Pennsylvania)

Process Technical Development Scientist (StemCells, Inc.)

Quality Assurance Specialist – Gene Transfer & Somatic Cell Engineering Facility (Memorial Sloan-Kettering Cancer Center)

Hematologist (NorthShore University Health System Medical Group)

Research Associate (University of Massachusetts Medical School)

Associate Scientist (St. Jude Children’s Research Hospital)

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