Volume 2.01 | Jan 11

Hematopoiesis News 2.01, January 11, 2011.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Stem Cell Discovery Could Lead to Improved Bone Marrow Transplants 
Researchers have identified a key molecule for establishing blood stem cells in their niche within the bone marrow. [Press release from the University of California, Santa Cruz discussing online prepublication in Cell Stem Cell]

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SCIENCE NEWS

UNC Researchers Inch Closer to Unlocking Potential of Synthetic Blood
A team of scientists has created particles that closely mirror some of the key properties of red blood cells, potentially helping pave the way for the development of synthetic blood. [Press release from The University of North Carolina at Chapel Hill discussing online prepublication in the Proceedings of the National Academy of Sciences]

Researchers Show How T-Beta 4 Protects Human Stem Cells
RegeneRx Biopharmaceuticals, Inc. reported that a team of cardiovascular researchers in China have shown that T-beta 4 can protect endothelial progenitor cells derived from the blood of healthy human volunteers. [Press release from RegeneRx Biopharmaceuticals, Inc. discussing online prepublication in the Journal of Cellular Physiology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches
Researchers demonstrate that the guidance molecule Robo4 functions to specifically anchor hematopoietic stem cells to bone marrow niches. [Cell Stem Cell]

Using Mechanobiological Mimicry of Red Blood Cells to Extend Circulation Times of Hydrogel Microparticles
Scientists synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red blood cells in size and shape, and tested their behavior in vivo. [Proc Natl Acad Sci USA]

Reduced NR4A Gene Dosage Leads to Mixed Myelodysplastic/Myeloproliferative Neoplasms in Mice
Investigators show that reduced gene dosage of NR4A1 and NR4A3 in hypoallelic (NR4A1+/-NR4A3-/- or NR4A1-/-NR4A3+/-) mice below a critical threshold leads to a chronic myeloid malignancy that closely recapitulates the pathological features of mixed myelodysplastic/myeloproliferative neoplasms with progression to acute myeloid leukemia in rare cases. [Blood]


FIP200, an Essential Component of Mammalian Autophagy is Indispensible for Fetal Hematopoiesis
Investigators show that mice lacking FIP200 in hematopoietic cells experience perinatal lethality associated with severe erythroblastic anemia. [Autophagy]

The ARID Family Transcription Factor Bright is Required for Both Hematopoietic Stem Cell and B Lineage Development
Results place Bright/Arid3a within a select list of transcriptional regulators required to program both hematopoietic stem cells and lineage-specific differentiation. [Mol Cell Biol]

Thymosin Beta-4 Activates Integrin-Linked Kinase and Decreases Endothelial Progenitor Cells Apoptosis Under Serum Deprivation
Researchers investigated the effect of thymosin beta-4 on endothelial progenitor cells apoptosis induced by serum deprivation and the corresponding signal transduction pathways involved in this process. [J Cell Physiol]

Differential Hox Expression in Murine Embryonic Stem Cell Models of Normal and Malignant Hematopoiesis
To investigate the role of the Hox network in normal and aberrant, early hematopoiesis, scientists employed an in vitro embryonic stem cell differentiation system, which recapitulates mouse developmental hematopoiesis. [Stem Cells Dev]

Increased c-Myc Activity and DNA Damage in Hematopoietic Progenitors Precede Myeloproliferative Disease in Spa-1-Deficiency
Investigators demonstrate that preleukemic, disease-free Spa-1-/- mice show reduced steady-state hematopoiesis and attenuated resistance to whole body gamma-ray irradiation, which are attributable to the sustained p53 response in hematopoietic progenitor cells. [Cancer Sci]

Erythropoiesis is Regulated by the Transcription Elongation Factor Foggy/Spt5 through Gata1 Gene Regulation
Researchers report that the positive function of Foggy/Spt5 is required for gata1 expression during zebrafish embryonic hematopoiesis. [Genes Cells]

CLINICAL RESEARCH

Hematopoietic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome in Children: Results of the EWOG-MDS 98 Study
Investigators report on the outcome of children with advanced primary myelodysplastic syndrome transplanted from an HLA-matched sibling or an unrelated donor following a preparative regimen with busulfan, cyclophosphamide and melphalan. [Leukemia]

Gene Expression Profile of Cytokines in Patients with Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation with Reduced Conditioning
Scientists evaluated 14 patients who received a reduced intensity conditioning hematopoietic stem cell transplantation. [Cytokine]


Nephrotic Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation: Etiology and Pathogenesis
Researchers investigated the etiology and pathogenesis of nephrotic syndrome after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 257 patients with hematopoietic malignancies who survived more than 2 months post allo-HSCT. [Blood Cells Mol Dis]

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INDUSTRY NEWS

Celgene Provides Update on Regulatory Submissions
Celgene International Sàrl announced regulatory submissions for its blood cancer therapies REVLIMID (lenalidomide) and ISTODAX (romidepsin). [Celgene Press Release]

Athersys Announces Completion of Patient Enrollment for Single Dose Arm of Phase I Study of MultiStem(R) for Hematopoietic Stem Cell Transplant Support
Athersys, Inc. announced that it has completed patient enrollment of the single dose arm of a clinical study involving administration of MultiStem® to patients being treated for leukemia or other blood born cancers. [Athersys Inc. Press Release]

SuperGen Announces Enrollment of First Patient in First in Human Trial of SGI-110 in MDS and AML Patients
SuperGen, Inc. announced that it has enrolled the first patient in its first in human study of SGI-110, a second-generation hypomethylating agent, in patients with intermediate-2 or high-risk myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). [SuperGen, Inc. Press Release]

Chimerix Commences CMX001 Open-Label Clinical Study for the Treatment of Patients with Life-Threatening or Serious dsDNA Viral Infections
Chimerix, Inc., announced that patient enrollment has begun in a multicenter, open-label clinical study of CMX001 (the CMX001-350 study) for the treatment of life-threatening or serious conditions caused by double-stranded DNA (dsDNA) viruses. [Chimerix, Inc. Press Release]

Senesco Technologies’ Lead Therapeutic Candidate SNS01-T Granted Orphan Drug Status from FDA for Treatment of Multiple Myeloma
Senesco Technologies, Inc., announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for the company’s lead drug candidate SNS01-T for treatment of multiple myeloma. [Senesco Technologies, Inc. Press Release]

Kiadis Pharma Signs License Agreement with Hospira to Commercialize ATIR™ in Europe and Asia – Partnership Would Advance Innovative Stem Cell Transplant Product
Kiadis Pharma announced that it has entered into a licensing agreement with Hospira, Inc. to develop and commercialize Kiadis Pharma’s ATIR™. [Kiadis Pharma Press Release]

University of Pittsburgh Cancer Institute Appoints New Director of Hematologic Malignancies Program
Clayton A. Smith, M.D., has been named director of the Hematologic Malignancies Program at the University of Pittsburgh Cancer Institute and director of Leukemia and Stem Cell Transplant Clinical Services with University of Pittsburgh Medical Center Cancer Centers. [University of Pittsburgh Medical Center Press Release]

Goodell Receives 2011 Edith and Peter O’Donnell Award for Medicine
Dr. Peggy Goodell was presented with the 2011 Edith and Peter O’Donnell award in medicine at the annual meeting of The Academy of Medicine, Engineering and Science of Texas Jan. 6-7, 2011, in Austin. [Baylor College of Medicine Press Release]

2011 Recipient of ASH-AMFDP Award will Study New Treatment for HTLV-1-Related Adult T-Cell Leukemia-Lymphoma
Adrienne Phillips, MD, MPH, has been selected to receive the American Society of Hematology and the Harold Amos Medical Faculty Development Program (ASH-AMFDP) Award to conduct research on HLTV-1 adult T-cell leukemia/lymphoma. [American Society of Hematology Press Release]




EVENTS 

NEW International Society for Laboratory Hematology
May 6-8, 2011
New Orleans, United States

NEW 16th Congress of the European Hematology Association
June 9-12, 2011
London, United Kingdom

NEW 11th International Conference on Malignant Lymphoma 
June 15-18, 2011
Lugano, Switzerland

Visit our events page to stay up to date with the latest events in the hematopoiesis community.

JOB OPPORTUNITIES

Lab Technologist – Cell Separation (STEMCELL Technologies)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)


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