Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Autophagy Regulates the Maturation of Hematopoietic Precursors in the Embryo

[Nature Communications] Using combined approaches, including scRNA-seq, researchers confirmed that autophagy-related gene 5 deletion interrupted developmental temporal order of endothelial to hematopoietic transition to further affect the pre-HSC I maturation.

Malignant Progression of Pre-Leukemic Disorders

[Blood] Scientists review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to AML.

Bone Marrow Inflammation in Hematological Malignancies

[Nature Reviews Immunology] The authors provide an overview of our current understanding of inflammatory changes in the bone marrow microenvironment of myeloid and lymphoid malignancies, using acute myeloid leukemia and multiple myeloma as examples and highlight unique and shared features of inflammation in niches for progenitor cells and plasma cells.

Translation Efficiency Driven by CNOT3 Subunit of the CCR4-NOT Complex Promotes Leukemogenesis

[Nature Communications] Investigators uncovered CNOT3, a subunit of the CCR4-NOT complex, as an essential modulator of translation in myeloid leukemia. Elevated CNOT3 expression correlated with unfavorable outcomes in patients with AML.

NFKBIE Mutations Are Selected by the Tumor Microenvironment and Contribute to Immune Escape in Chronic Lymphocytic Leukemia

[Leukemia] Researchers showed that NFKBIE-mutated CLL cells were selected by microenvironmental signals that activate the NF-κB pathway and induced alterations within the tumor microenvironment that can allow for immune escape, including expansion of CD8+ T cells with an exhausted phenotype and increased PD-L1 expression on the malignant B cells.

Impact of Clonal Hematopoiesis of Indeterminate Potential on Hepatocellular Carcinoma in Individuals with Steatotic Liver Disease

[Hepatology] Investigators examined whether clonal hematopoiesis of indeterminate potentia was associated with HCC development in patients with steatotic liver disease.

Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

[Journal Of Clinical Oncology] Adults with FLT3-ITD AML in first remission underwent hematopoietic cell transplantation (HCT) and were randomly assigned to placebo or 120mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival.

STAT3 Protects Hematopoietic Stem Cells by Preventing Activation of a Deleterious Autocrine Type-I Interferon Response

[Leukemia] Scientists developed mixed bone marrow chimeric mice with inducible Stat3 deletion in 20% of the hematopoietic compartment to avoid systemic inflammation. Stat3-deficient HSPCs were significantly impaired in reconstitution ability following primary or secondary bone marrow transplantation, indicating hematopoietic stem cell defects.

FDA Approves Inotuzumab Ozogamicin for Pediatric CD22+ B-Cell Precursor Acute Lymphoblastic Leukemia

[OncLive] The FDA has approved inotuzumab ozogamicin for the treatment of pediatric patients aged one year and older with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia.

Osteomacs Promote Maintenance of Murine Hematopoiesis Through Megakaryocyte-Induced Upregulation of Embigin and CD166

[Stem Cell Reports] The authors characterized osteomacs (OMs) and identify megakaryocyte-induced mediators that augment the role of OM in the niche. Single-cell mRNA-seq, mass spectrometry, and CyTOF examination of megakaryocyte-stimulated OM suggested that upregulation of CD166 and Embigin on OM augment their hematopoiesis maintenance function.

A Mitochondrial NADPH-Cholesterol Axis Regulates Extracellular Vesicle Biogenesis to Support Hematopoietic Stem Cell Fate

[Cell Stem Cell] Investigators showed that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, which are required for proper HSC cell fate and homeostasis.

Joint Analysis of Mutational and Transcriptional Landscapes in Human Cancer Reveals Key Perturbations During Cancer Evolution

[Genome Biology] Scientists analyzed cancer evolution and clonal selection by jointly considering mutational and transcriptomic profiles of single cells acquired from tumor biopsies from 49 lung cancer samples and 51 samples with chronic myeloid leukemia.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

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