Volume 11.24 | Jun 23

2020-23-06 | HN 11.24
Hematopoiesis News by STEMCELL Technologies
Vol. 11.24 – 23 June, 2020

Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development

Scientists used single-cell RNA sequencing to interrogate the rare CD34+ progenitor and the more differentiated CD34 fractions in the human postnatal thymus.

AbstractGraphical Abstract

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Diaphanous-Related Formin mDia2 Regulates Beta2 Integrins to Control Hematopoietic Stem and Progenitor Cell Engraftment

Investigators showed that loss of diaphanous-related formin mDia2 led to impaired engraftment of long-term hematopoietic stem cells and loss of competitive hematopoietic stem and progenitor cell repopulation.
[Nature Communications]

Full Article

A Missense Mutation in the MLKL Brace Region Promotes Lethal Neonatal Inflammation and Hematopoietic Dysfunction

The authors isolated a mouse strain with a single missense mutation, MlklD139V, that altered the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory pseudokinase domains.
[Nature Communications]

Full Article

Synthetic Lethal Targeting of TET2-Mutant Hematopoietic Stem and Progenitor Cells (HSPCs) with TOP1-Targeted Drugs and PARP1 Inhibitors

Researchers tested 129 FDA-approved anticancer drugs in a tet2-deficient zebrafish model and showed that topoisomerase 1 (TOP1)-targeted drugs and PARP1 inhibitors selectively killed tet2-mutant HSPCs.


S100A6 Is a Critical Regulator of Hematopoietic Stem Cells

Scientists showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC.

Full Article

Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.


Enhanced Collection of Phenotypic and Engrafting Human Cord Blood Hematopoietic Stem Cells at 4°C

Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells.
[Stem Cells]


ADP Receptor P2y12 Prevents Excessive Primitive Hematopoiesis in Zebrafish by Inhibiting Gata1

By using mass spectrometry combined with RNA sequencing, scientists showed that absence of P2y12 induced excessive erythropoiesis, evidenced by significantly increased expression of mature erythrocytes marker α-globin, β-globin.
[Acta Pharmacologica Sinica]


Biomimetic Reconstruction of the Hematopoietic Stem Cell Niche for In Vitro Amplification of Human Hematopoietic Stem Cells

To model the natural HSC niche in vitro, researchers optimized the HSC medium composition with a panel of cytokines and valproic acid and used an artificial 3D bone marrow-like scaffold made of polydimethylsiloxane.
[PLoS One]

Full Article

Allogeneic Hematopoietic Stem Cell Transplantation from a 2-HLA-Haplotype-Mismatched Family Donor for Posttransplant Relapse: A Prospective Phase I/II Study

In order to explore the possibility of HLA-mismatched hematopoietic stem cell transplantation from family donors beyond haploidentical relatives, investigators conducted a prospective Phase I/II study of 2-HLA-haplotype-mismatched hematopoietic stem cell transplantation.
[Bone Marrow Transplantation]


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MLLT10 in Benign and Malignant Hematopoiesis

The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
[Experimental Hematology]

AbstractGraphical Abstract


Marker Therapeutics Receives USAN Approval for "Zelenoleucel" as Nonproprietary Name for MT-401, Multi-Tumor-Associated Antigen Targeted T Cell Product for Acute Myeloid Leukemia

Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings.
[Marker Therapeutics, Inc.]

Press Release

IMBRUVICA® (Ibrutinib) Seeks to Expand US Label with Long-Term Data in Waldenström’s Macroglobulinemia (WM)

AbbVie announced that the FDA will review a supplemental New Drug Application for IMBRUVICA® in combination with rituximab for the treatment of WM, a rare and incurable type of non-Hodgkin’s lymphoma.
[AbbVie Inc.]

Press Release

Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]



Myeloma and Plasma Cell Dyscrasias

2020-10-02 – 2020-10-05
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Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

Lund University – Lund, Sweden

Postdoctoral Position – Immune Privilege of the Stem Cell Niche

Columbia University – New York, New York, United States

Postdoctoral Fellow – Hematopoietic Stem Cell Biology

University of Illinois at Chicago – Chicago, Illinois, United States

PhD Student Position – Epigenetic Regulation of Hematopoietic Stem Cells

Karolinska Institutet – Huddinge, Sweden

PhD Studentship – Erythropoiesis

University of Bristol – Bristol, United Kingdom

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