Volume 11.23 | Jun 16

2020-16-06 | HN 11.23
Hematopoiesis News by STEMCELL Technologies
Vol. 11.23 – 16 June, 2020

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Researchers showed that Bacille-Calmette-Guérin vaccination in healthy human volunteers induced a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell compartment in the bone marrow.
[Cell Host & Microbe]

Full ArticleGraphical Abstract

Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
PUBLICATIONSRanked by the impact factor of the journal

Hematopoietic Stem and Progenitor Cell-Restricted Cdx2 Expression Induces Transformation to Myelodysplasia and Acute Leukemia

Investigators developed a conditionally inducible Cdx2 mouse model to determine the effects of in vivo, inducible Cdx2 expression in hematopoietic stem and progenitor cells.
[Nature Communications]

Full Article

An Erg-Driven Transcriptional Program Controls B Cell Lymphopoiesis

The authors showed that the transcription factor ETS Related Gene (Erg) was essential for early B lymphoid differentiation. Erg initiated a transcriptional network involving the B cell lineage defining genes, Ebf1 and Pax5, which directly promoted expression of key genes involved in V(D)J recombination and formation of the B cell receptor.
[Nature Communications]

Full Article

Nuclear Interacting SET Domain Protein 1 Inactivation Impairs GATA1-Regulated Erythroid Differentiation and Causes Erythroleukemia

Scientists showed that nuclear receptor binding SET domain protein 1 knockdown alters erythroid clonogenic growth of human CD34+ hematopoietic cells.
[Nature Communications]

Full Article

Reduced CXCR4-Expression on CD34-Positive Blood Cells Predicts Outcomes of Persons with Primary Myelofibrosis

Researchers analyzed the relevance of cytofluorimetric assessment of the percentage of CD34-positive blood cells that had a positive CXCR4 surface expression in a large cohort of subjects with myeloproliferative neoplasms.


Knock-Out of Hopx Disrupts Stemness and Quiescence of Hematopoietic Stem Cells in Mice

Scientists generated a mouse model with hematopoietic cell-specific knockout of Hopx (Hopx−/−). In young Hopx−/− mice, the HSCs showed decreased reconstitution ability after serial transplantation.


Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

The authors established an efficient CRISPR/Cas9-based mixed lineage leukemia rearrangements model in hematopoietic stem and progenitor cells (HSPCs) derived from human cord blood (huCB) and faithfully mimicked the underlying biology of the disease. They applied this model to HSPCs from adult bone marrow to investigate the impact of the cell of origin and fusion partner on disease development.

Full Article

Risk Score to Predict Event-Free Survival after Hematopoietic Cell Transplant for Sickle Cell Disease

Investigators developed a risk score to predict event-free survival after allogeneic hematopoietic cell transplantation for sickle cell disease.


Clonal Hematopoiesis Is Associated with Adverse Outcomes in Multiple Myeloma Patients Undergoing Transplant

Targeted sequencing of the stem cell product from 629 multiple myeloma patients treated by autologous stem cell transplant at the Dana-Farber Cancer Institute detected clonal hematopoiesis of indeterminate potential in 136/629 patients.
[Nature Communications]

Full Article

SepMate™ PBMC Isolation

MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development]

Full ArticleGraphical Abstract


Partner Therapeutics Announces Initiation of Clinical Trial Evaluating Leukine® in T Cell Replete HLA-mismatched Haploidentical Stem Cell Transplant

Partner Therapeutics announced the enrollment of the first patient dosed in a Phase II investigator-initiated study evaluating the efficacy and safety of Leukine® in T cell replete HLA-mismatched haploidentical stem cell transplant recipients who are receiving post-transplant cyclophosphamide.
[Partner Therapeutics, Inc.]

Press Release

Curis Announces FDA Clearance of IND Application for CI-8993, the First-In-Class Monoclonal Anti-VISTA Antibody

Curis, Inc. announced that the FDA has cleared its Investigational New Drug (IND) application for CI-8993, the first-in-class monoclonal anti-VISTA antibody.
[Curis, Inc.]

Press Release

Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]


Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.



Keystone eSymposia | Advances in Cancer Immunotherapy

2020-08-17 – 2020-08-19

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Postdoctoral Position – Immune Privilege of the Stem Cell Niche

Columbia University – New York, New York, United States

Postdoctoral Fellow – Hematopoietic Stem Cell Biology

University of Illinois at Chicago – Chicago, Illinois, United States

PhD Student Position – Epigenetic Regulation of Hematopoietic Stem Cells

Karolinska Institutet – Huddinge, Sweden

PhD Student Position – Leukemic Stem Cell Immune Targeting

Karolinska Institutet – Huddinge, Sweden

PhD Studentship – Erythropoiesis

University of Bristol – Bristol, United Kingdom

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

The University of Texas Southwestern Medical Center – Dallas, Texas, United States

Postdoctoral Fellow – Molecular Hematology

Heidelberg University Hospital – Heidelberg, Germany

Postdoctoral Position – Tumor Immunology

University of Maryland – Baltimore, Maryland, United States

Postdoctoral Position – Leukemia

Josep Carreras Leukaemia Research Institute – Barcelona, Spain

Postdoctoral Position – Immunology/Molecular Biology

NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States

PhD Position – Leukemic Stem Cells and Metabolism

University of Bern – Bern, Switzerland

Postdoctoral Fellow – Hematopoiesis Research

Harvard Medical School – Boston, Massachusetts, United States

Assistant/Associate Professor – Hematology & Oncology

UC Davis School of Medicine – Davis, California, United States

Associate/Professor – Hematology & Oncology

UC Davis School of Medicine – Davis, California, United States

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