Volume 1.40 | Oct 19

Hematopoiesis News 1.40, October 19, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Gene Identified That Prevents Stem Cells From Turning Cancerous  ShareThis
New research shows that having too many stem cells, or stem cells that live for too long, can increase the odds of developing cancer. By identifying a mechanism that regulates programmed cell death in hematopoietic stem cells, the work is the first to connect the death of such cells to a later susceptibility to tumors in mice.[Press release from Rockefeller University discussing online prepublication in Genes and Development]

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SCIENCE NEWS

Research Shows a Promising New Method to Reduce Graft-Versus-Host-Disease After Bone Marrow Transplantation
Researchers have discovered a new method to prevent the immune-system attacks that often occur following bone marrow transplants. [Press release from the University of Michigan discussing online prepublication in Blood]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Sept4/ARTS Is Required for Stem Cell Apoptosis and Tumor Suppression
Here, researchers show that deletion of the mouse Sept4 gene, which encodes the inhibitor of apoptosis protein antagonist ARTS, promotes tumor development. [Genes Dev]

Notch Signaling Is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease
Results identify Notch as a novel essential regulator of pathogenic CD4+ T cell responses during acute graft-versus-host disease and suggest that Notch signaling in T cells should be investigated as a therapeutic target following allogeneic hematopoietic stem cell transplantation. [Blood]

Aberrant Global Methylation Patterns Affect the Molecular Pathogenesis and Prognosis of Multiple Myeloma
Researchers have used genome-wide methylation microarrays to analyze differences in CpG methylation patterns in cells relevant to the pathogenesis of myeloma plasma cells, including B cells, normal plasma cells, MGUS, presentation myeloma, and plasma cell leukemia. [Blood]

Chemoproteomics-Based Kinome Profiling and Target Deconvolution of Clinical Multi-Kinase Inhibitors in Primary Chronic Lymphocytic Leukemia Cells
Researchers profiled a panel of clinical multi-kinase inhibitors for their ability to induce apoptosis in primary chronic lymphocytic leukemia cells. [Leukemia]

Arsenic-Induced, SUMO-Dependent Recruitment of RNF4 Into PML Nuclear Bodies
Here, researchers analyzed the nuclear trafficking dynamics of promyelocytic leukemia and its SUMO-dependent ubiquitin E3 ligase, RNF4 in response to arsenic. [Mol Biol Cell]

Oncoprotein Cot1 Represses Kinase Suppressors of Ras1/2 and 1,25-Dihydroxyvitamin D3-Induced Differentiation of Human Acute Myeloid Leukemia Cells
Here, researchers show that the product of protooncogene Cot1 represses the monocytic phenotype in human acute myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3 (1,25D), even though the expression of cellular Cot1 increases early in the process of 1,25D-induced differentiation. [J Cell Physiol]

CLINICAL RESEARCH

Immune Reconstitution After Haploidentical Hematopoietic Cell Transplantation: Impact of Reduced Intensity Conditioning and CD3/CD19 Depleted Grafts
Researchers report on 28 patients after haploidentical hematopoietic cell transplantation with CD3/CD19-depleted grafts using reduced intensity conditioning, which were prospectively evaluated for engraftment and immune reconstitution. [Leukemia]

INDUSTRY NEWS

Seattle Genetics Reports Preliminary Data from Phase I Clinical Trial of SGN-75
Seattle Genetics, Inc. reported data from a phase I clinical trial of SGN-75 in patients with non-Hodgkin lymphoma or renal cell carcinoma. Preliminary results demonstrate tolerability and antitumor activity, including two objective responses in the first 16 patients treated. [Seattle Genetics, Inc. Press Release]

CyDex Pharmaceuticals Obtains Full Development and Commercialization Rights to Novel Captisol-Enabled(R) Intravenous Formulation of Clopidogrel
CyDex Pharmaceuticals, Inc. announced a mutual decision with Prism Pharmaceuticals to terminate their existing joint development agreement on novel Captisol(R)-enabled intravenous formulations of clopidogrel. [CyDex Pharmaceuticals, Inc. Press Release]

POLICY NEWS

European Medicines Agency Strengthens Rules on Conflicts of Interests of Its Scientific Experts
The European Medicines Agency has published new rules on how the Agency will be handling potential conflicts of interests of its scientific experts, following endorsement by its Management Board. [European Medicines Agency, European Union]

IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials
If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany]

Loss of UK Genetics Public Bodies Confirmed
The official announcement from the UK Government on the future of non-departmental public bodies has confirmed the rumored abolition of a total of 192 public bodies, with a further 118 to be merged. [Foundation for Genomics and Population Health, United Kingdom]

More Legal Jousting in Stem Cell Case
The two sides in the ongoing court battle over stem cell research filed another batch of legal documents in response to court-ordered deadlines.  [Court of Appeals, United States]

HHS to Let Secretary’s Genetics Committee Expire 
The Secretary’s Advisory Committee on Genetics, Health, and Society will disband next month, eight years after its founding. The committee had completed its original task, advising the Department of Health and Human Services (HHS) on a number of issues related to genomics. [Department of Health and Human Services, United States]

Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2010-25646) [Department of Health and Human Services, United States]

Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA (FR Doc. 2010-25728) [Department of Health and Human Services, United States]

Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States]

Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States]

Partnerships To Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]


EVENTS (Listed by Date)

6th Modern Drug Discovery & Development Summit (M3D)
October 20-22, 2010
San Francisco, United States

American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference
October 21-22, 2010
Washington, DC, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

NEW  5th UK Cancer Stem Cell Symposium
November 2, 2010
London, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
November 17-19, 2010
Sonoma, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

NEW  5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada

Highlights of American Society of Hematology (ASH) Washington, DC
January 28-29, 2011
Washington, DC, United States

Highlights of American Society of Hematology (ASH) San Francisco
January 28-29, 2011
San Francisco, United States

Highlights of American Society of Hematology (ASH) New York
February 4-5, 2011
New York, United States

Highlights of American Society of Hematology (ASH) San Diego
February 4-5, 2011
San Diego, United States

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

NEW  Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

37th Annual Meeting of the European Group for Blood and Marrow Transplantation
April 3-6, 2011
Paris, France

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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