Volume 1.39 | Oct 12

Hematopoiesis News 1.39, October 12, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner  ShareThis
Here, researchers examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of immature osteoblastic cells. Ebf2-/- mice show decreased frequencies of hematopoietic stem cells and lineage-committed progenitors. [Cell Stem Cell]

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SCIENCE NEWS

Scripps Research Scientists Reveal First Structure of a Class of Proteins that Sniff Out Signals Guiding Blood Cell Movement
Researchers have determined the structure of a protein that helps guide hematopoietic stem cells. The protein is also one of the main receptors used by the human immunodeficiency virus (HIV) to get inside blood cells. [Press release from The Scripps Research Institute discussing online prepublication in Science]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Structures of the CXCR4 Chemokine GPCR With Small-Molecule and Cyclic Peptide Antagonists
Here, researchers report five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution. [Science]

Early Lymphocyte Recovery Following Intensive Timed Sequential Chemotherapy for Acute Myelogenous Leukemia: Peripheral Oligoclonal Expansion of Regulatory T Cells
To test the hypothesis that lymphocyte recovery mirrors ontogeny, researchers characterized early lymphocyte recovery and attendant cytokine profiles in twenty consecutive patients undergoing induction timed sequential chemotherapy for newly diagnosed acute myelogenous leukemia. [Blood]

HMGB1-Induced Autophagy Promotes Chemotherapy Resistance in Leukemia Cells
Here, researchers show that high-mobility group box 1 (HMGB1), the best characterized damage-associated molecular pattern, was released from leukemia cell lines after chemotherapy-induced cytotoxicity and activated autophagy to protect against injury. [Leukemia]

A DEAB-Sensitive Aldehyde Dehydrogenase Regulates Hematopoietic Stem and Progenitor Cells Development During Primitive Hematopoiesis in Zebrafish Embryos
Although aldehyde dehydrogenase activity has become a surrogate of hematopoietic stem and progenitor cells, its function during hematopoiesis was unclear. Here, researchers examined its role in zebrafish hematopoiesis based on pharmacological inhibition and morpholino knockdown. [Leukemia]

The Combination of a Histone Deacetylase Inhibitor With the BH3-Mimetic GX15-070 has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy
Researchers analyzed the cellular and molecular effects of two different histone deacetylase inhibitors, MGCD0103 and vorinostat, in combination with GX15-070, a BH3-mimetic, in acute myeloid leukemia (AML) cell lines and primary AML cells, and demonstrated that the combination has a synergistic antileukemia effect. [Autophagy]

Riccardin D, a Novel Macrocyclic Bisbibenzyl, Induces Apoptosis of Human Leukemia Cells by Targeting DNA Topoisomerase II
Researchers studied the effect of riccardin D, a macrocyclic bisbibenzyl, which was isolated from the Chinese liverwort plant, on human leukemia cells and the underlying molecular mechanism. [Invest New Drugs]

CLINICAL RESEARCH

Secondary Solid Cancers After Allogeneic Hematopoietic Cell Transplantation Using Busulfan-Cyclophosphamide Conditioning
Researchers evaluated the incidence and risk-factors for solid cancers after hematopoietic-cell transplant (HCT) using myeloablative busulfan-cyclophosphamide (Bu-Cy) conditioning in 4,318 recipients of first allogeneic HCT for acute myeloid leukemia in first complete remission (N=1,742) and chronic myeloid leukemia in first chronic phase (N=2,576). [Blood]

INDUSTRY NEWS

NIH Funds Center of Excellence for Molecular Hematology at Cincinnati Children’s
The National Institute of Diabetes, Digestive and Kidney Diseases, one of 19 National Institutes of Health, has approved a five-year, $3.4 million grant for Cincinnati Children’s to establish the multi-disciplinary center. [Cincinnati Children’s Hospital Press Release]

Mylan Receives Approval for Fludarabine Phosphate Injection, USP
Mylan Inc. announced that its subsidiary Bioniche Pharma received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Fludarabine Phosphate Injection USP, 25 mg/mL, packaged in 50 mg/2 mL Single-dose Vials. [Mylan Inc. Press Release]

Cepheid Collaborates With Pharmaceutical Leader on Chronic Myelogenous Leukemia
Cepheid announced an exclusive collaboration with Novartis for the commercialization of a test for monitoring the BCR-ABL gene transcript in peripheral blood specimens from patients diagnosed with Philadelphia chromosome-positive chronic myelogenous leukemia. [Cepheid Press Release]

STEMSOFT® Software Inc. Licenses StemLab® Software to The Blood Connection
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the licensing of StemLab, the leading cell therapy transplant and cord blood banking laboratory software, to The Blood Connection in Piedmont, South Carolina. [STEMSOFT Software Inc. Press Release]

STEMSOFT Connect – A Simplified Solution to a Complex Problem
STEMSOFT is pleased to announce the release of their new standard interfaces, STEMSOFT Connect™.  STEMSOFT Connect offers standard interface tools that easily connect commonly used applications and devices to STEMSOFT’s applications. [STEMSOFT Software Inc. Press Release]


POLICY NEWS

NIH Announces New Program to Accelerate Research Independence
The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States]

FDA’s $25 Million Pitch for Improving Drug Regulation
The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States]

FDA to Push for More Investment in Science
Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States]

FDA Issues Regulatory Science Report
The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States]

Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-25176) [National Institutes of Health, United States]

November 16-17, 2010: Vaccines and Related Biological Products Advisory Committee Meeting Announcement [Food and Drug Administration, United States]


EVENTS (Listed by Date)

National Marrow Donor Program (NMDP) 2010 Council Meeting
October 15-16, 2010
Minneapolis, United States

‘HAA 2010’ – The Combined Annual Scientific Meeting of HSANZ, ANZSBT AND ASTH
October 17-20, 2010
Auckland, New Zealand

6th Modern Drug Discovery & Development Summit (M3D)
October 20-22, 2010
San Francisco, United States

American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference
October 21-22, 2010
Washington, DC, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
November 17-19, 2010
Sonoma, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada

Highlights of American Society of Hematology (ASH) Washington, DC
January 28-29, 2011
Washington, DC, United States

Highlights of American Society of Hematology (ASH) San Francisco
January 28-29, 2011
San Francisco, United States

Highlights of American Society of Hematology (ASH) New York
February 4-5, 2011
New York, United States

Highlights of American Society of Hematology (ASH) San Diego
February 4-5, 2011
San Diego, United States

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

37th Annual Meeting of the European Group for Blood and Marrow Transplantation
April 3-6, 2011
Paris, France

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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