Volume 1.35 | Sep 14

Hematopoiesis News 1.37, September 28, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Inhibiting Cell Signaling Pathway May Improve Bone Marrow Transplant Success Rate  ShareThis
Identification of a molecular communications pathway that influences the mobilization of hematopoietic stem cells could lead to targeted therapies for improving bone marrow transplant success rates. [Press release from Cincinnati Children’s Hospital Medical Center discussing online prepublication in Nature Medicine]

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SPECIAL FEATURE

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SCIENCE NEWS

Researchers Discover New Signaling Pathway That Controls Cell Development and Cancer
Researchers have discovered a new cell signaling pathway that controls cell growth and development, a pathway that when defective helps promote the formation of several major forms of human cancer including lymphoma and leukemia. [Press release from the UCLA Jonsson Comprehensive Cancer Center discussing online prepublication in Molecular Cell]

Shorter Length of Biological Marker for Patients With Aplastic Anemia Associated with Higher Rate of Relapse, Death
Among patients receiving immunosuppressive therapy for severe aplastic anemia, the length of telomeres was not related to the response to treatment but was associated with a higher rate of relapse and lower overall survival, according to a study. [Press release from JAMA News discussing online prepublication in the Journal of the American Medical Association]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Pharmacological Inhibition of EGFR Signaling Enhances G-CSF-Induced Hematopoietic Stem Cell Mobilization
The findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provided a new pharmacological approach for improving hematopoietic stem and progenitor cell mobilization and thereby transplantation outcomes. [Nat Med]

AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling
Data show that CRTC2 inactivation, via physiologic DNA damage response signaling, promotes B cell differentiation in response to genotoxic stress. [Mol Cell]

Notch Signaling is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease
Here, researchers reported that Notch signaling is a potent regulator of T cell activation, differentiation and function during acute graft-versus-host disease. [Blood]

Autocrine/Paracrine Cytokine Stimulation of Leukemic Cell Proliferation in Smoldering and Chronic Adult T Cell Leukemia
Researchers demonstrated that smoldering/chronic adult T cell leukemia (ATL) PBMC spontaneously proliferated ex vivo in a cytokine (IL-2/IL-9/IL-15) dependent manner while acute type ATL PBMC did not proliferate or proliferated independent of cytokines. [Blood]

High-Definition Mapping of Retroviral Integration Sites Identifies Active Regulatory Elements in Human Multipotent Hematopoietic Progenitors
High-definition MLV integration maps provide a rational basis for predicting genotoxic risks in gene therapy, and a new tool for genome-wide identification of promoters and regulatory elements controlling hematopoietic stem and progenitor cell functions. [Blood]

Ligation of Complement Receptor 1 Increases Erythrocyte Membrane Deformability
Researchers show that ligation of red blood cell complement receptor 1 (RBC CR1) by antibody and complement-opsonized particles induces a transient Ca++ influx that is proportional to the RBC CR1 levels and is inhibited by T1E3 polyclonal antibody, a specific inhibitor of TRPC1 channels. [Blood]

Adiponectin and Heme Oxygenase-1 Suppress TLR4/MyD88-Independent Signaling in Rat Kupffer Cells and in Mice after Chronic Ethanol Exposure
Here, researchers investigated the interactions between chronic ethanol, adiponectin, and heme oxygenase-1 in regulation of TLR4/MyD88-independent signaling in macrophages and an in vivo mouse model. [J Immunol]

CLINICAL RESEARCH

Association of Telomere Length of Peripheral Blood Leukocytes With Hematopoietic Relapse, Malignant Transformation, and Survival in Severe Aplastic Anemia
The objective of this study was to investigate the relationship between telomere length and clinical outcomes in severe aplastic anemia. [JAMA]

Clinical and Genetic Features of Therapy-Related Myeloid Neoplasms after Chemotherapy for Acute Promyelocytic Leukemia
Researchers attempted to clarify the different clinical features and hematological findings between therapy-related myeloid neoplasms (t-MN) and relapse cases, and to identify gene alterations involved in t-MN. [Blood]

Reduced-Intensity Conditioning Significantly Improves Survival of Patients with Hemophagocytic Lymphohistiocytosis Undergoing Allogeneic Hematopoietic Cell Transplantation
Researchers conclude that reduced-intensity conditioning significantly improves the outcome of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation. [Blood]

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INDUSTRY NEWS

Masonic Cancer Center Receives $26 Million to Lead National Blood and Bone Marrow Cancer Research
Two of the University of Minnesota Masonic Cancer Center’s leading physician-scientists on research and treatment of cancers of the blood and bone marrow have received renewed five-year program project research grants totaling almost $26 million from the National Cancer Institute. [University of Minnesota Masonic Cancer Center Press Release]

University of South Florida Stem Cell Scientists Call for Research Ethics Consortium
Two University of South Florida stem cell researchers propose creating an independent national “Stem Cell Research Ethics Consortium” to provide better guidance on stem cell issues for regulatory agencies, law makers and policy makers. [University of South Florida Press Release]

CSL Shares Rise as Rival Product Recalled in Europe, U.S. on Blood Clots
CSL Ltd., the world’s second-biggest maker of treatments derived from blood, rose the most in seven months in Sydney trading on speculation it will benefit from a recall of a competitor’s product in the U.S. and Europe. [Bloomberg]


POLICY NEWS

NIH Releases Biennial Report of the Director
Dr. Francis S. Collins, M.D., Ph.D, director of the National Institutes of Health, announced the release of the Biennial Report of the Director, NIH, for fiscal years 2008 and 2009. The report provides an integrated portrait of NIH research activities, making it easy for Congress, advocates and patient groups and the general public to understand the many activities of the agency. [National Institutes of Health, United States]

The NCI Cancer Immunotherapy Trials Network (CITN) Seeks Member Clinical Sites (NOT-CA-10-034) [National Institutes of Health, United States]

Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology (SBIR [U43/U44]) (PAR-10-286) [National Institutes of Health, United States]

Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of Meeting (FR Doc. 2010-23947) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-23852) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-23847) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-23849) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23860) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23952) [National Institutes of Health, United States]

National Cancer Institute; Notice of Meeting (FR Doc. 2010-23543) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-23545) [National Institutes of Health, United States]


EVENTS (Listed by Date)

Stem Cells and Regeneration – NIH Sponsored Advanced Training Courses
October 3-9, 2010
Woods Hole, United States

American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

NEW  National Marrow Donor Program (NMDP) 2010 Council Meeting
October 15-17, 2010
Minneapolis, United States

‘HAA 2010’ – The Combined Annual Scientific Meeting of HSANZ, ANZSBT AND ASTH
October 17-20, 2010
Auckland, New Zealand

NEW  6th Modern Drug Discovery & Development Summit (M3D)
October 20-22, 2010
San Francisco, United States

NEW American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference
October 21-22, 2010
Washington, DC, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

NEW 9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

NEW  22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

NEW  9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
November 17-19, 2010
Sonoma, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada

Highlights of American Society of Hematology (ASH) Washington, DC and San Francisco
January 28-29, 2011
Washington, DC and San Francisco, United States

Highlights of American Society of Hematology (ASH) New York and San Diego
February 4-5, 2011
New York and San Diego, United States

NEW BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

37th Annual Meeting of the European Group for Blood and Marrow Transplantation
April 3-6, 2011
Paris, France

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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