Volume 1.33 | Aug 31

Hematopoiesis News 1.33, August 31, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Early Mammalian Erythropoiesis Requires the Dot1L Methyltransferase  ShareThis
Researchers analyzed Dot1L mutant mice to determine the influence of this enzyme on embryonic hematopoiesis. [Blood]


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Human Umbilical Cord Blood Cells Aid Lab Animal Brain Cell Survival After Simulated Stroke
Human umbilical cord blood cells used to treat cultured rat brain cells deprived of oxygen appear to protect astrocytes from cell death after stroke-like damage. [Press release from EurekAlert! discussing online prepublication in Stem Cell Reviews and Reports]

CAS Chemistry Research Report: A Decade Later Human Genome Discoveries Spur Growth of Cancer Treatments
Leukemia patients who have struggled with cancer therapy resistance and intolerance will now have more options thanks to targeted drug therapy. Such new treatment options are due, in part, to a rapid increase in journal and patent publications following the discovery of Gleevec. [Chemical Abstracts Service Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)


Tissue Transglutaminase Contributes to the All-Trans Retinoic Acid Induced Differentiation Syndrome Phenotype in the NB4 Model of Acute Promyelocytic Leukemia
Researchers propose that reduced expression of transglutaminase 2 in differentiating acute promyelocytic leukemia cells may suppress effector functions of neutrophil granulocytes and attenuate the all-trans -retinoic acid-induced inflammatory phenotype of differentiation syndrome. [Blood]

Hedgehog Signaling Maintains Chemoresistance in Myeloid Leukemic Cells
In this study, researchers show that the chemotherapy-resistant phenotype of myeloid leukemia cells correlates with activation of the Hedgehog pathway, whereas in chemosensitive cells, such activation is less pronounced. [Oncogene]

A Functional SUMO-Interacting Motif in the Transactivation Domain of c-Myb Regulates its Myeloid Transforming Ability
Using both a myeloid cell line-based assay and a primary hematopoietic cell assay, researchers addressed the transforming abilities of SUMO binding and conjugation mutants. [Oncogene]

Arsenic Trioxide Induces Apoptosis through JNK and ERK in Human Mesothelioma Cells
These results indicated that As2O3 induces apoptosis of NCI-H2052 cells mainly through JNK1/2 activation, and that ERK1/2 is involved in As2O3-induced apoptosis when JNK1/2 are inactivated. [J Cell Physiol]

Regulation of the PML Tumor Suppressor in Drug-Induced Senescence of Human Normal and Cancer Cells by JAK/STAT-Mediated Signaling
Here, researchers show that genotoxic drugs that induce senescence, such as 5-bromo-2’deoxyuridine, thymidine, distamycin A, aphidicolin, etoposide and camptothecin all evoke expansion of Promyelocytic leukemia protein nuclear compartment and its association with persistent DNA lesions in several human cancer cell lines and normal diploid fibroblasts. [Cell Cycle]

Prospective Evaluation of Allogeneic Hematopoietic Stem-Cell Transplantation From Matched Related and Matched Unrelated Donors in Younger Adults With High-Risk Acute Myeloid Leukemia: German-Austrian Trial AMLHD98A
This study assesses the impact of allogeneic hematopoietic stem-cell transplantation from matched related donors and matched unrelated donors on outcome in high-risk patients with acute myeloid leukemia within a prospective multicenter treatment trial. [J Clin Oncol]

Prognosis of Binet Stage A Chronic Lymphocytic Leukemia Patients: The Strength of Routine Parameters
Researchers propose an easy, fast, cost-effective strategy for a trustworthy prognostication in stage A patients, who currently represent over 80% of the chronic lymphocytic leukemia population, allowing physicians to adapt follow-up individually. [Blood]

Th17 Immune Responses Contribute to the Pathophysiology of Aplastic Anemia
Th17 immune responses contribute to aplastic anemia pathohysiology, especially at the early stage during disease progression. [Blood]

Treatment of Patients with Relapsed/Refractory Multiple Myeloma with Lenalidomide and Dexamethasone With or Without Bortezomib: Prospective Evaluation of the Impact of Cytogenetic Abnormalities and of Previous Therapies
Researchers prospectively studied the impact of several cytogenetic abnormalities in patients with relapsed/refractory myeloma who received lenalidomide and dexamethasone with or without the addition of bortezomib. [Leukemia]


Cerus Signs Agreement to Acquire INTERCEPT Blood System Asian Commercial Rights from BioOne
Cerus Corporation announced that it has signed an agreement to acquire BioOne Corporation’s commercialization rights for the INTERCEPT Blood System for platelets and plasma, subject to approval of the transaction by BioOne’s shareholders. [Cerus Corporation Press Release]

Isotechnika Pharma and 3SBio Announce Strategic Partnership to Develop and Commercialize Voclosporin in China
Isotechnika Pharma Inc. and 3SBio Inc. announced the signing of a development and commercialization agreement for voclosporin, a next generation calcineurin inhibitor being developed for use in the prevention of organ rejection following transplantation and the treatment of autoimmune diseases. [Isotechnika Pharma Inc. Press Release]

Sanofi’s Bid to Block Lovenox Copy Denied by Judge
Sanofi-Aventis SA’s request to bar the U.S. Food and Drug Administration from allowing sales of a generic rival to its Lovenox blood thinner was rejected by a federal judge. [Businessweek]


Court Sides With State in Baby Blood Storage Case
Minnesota did not violate families’ privacy rights by collecting and storing children’s blood samples, the state Court of Appeals ruled. [Counthouse News Service]

NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]

NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]

EVENTS (Listed by Date)

The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
September 21-24, 2010
Washington D.C., United States

American Society of Hematology (ASH) State-of-the-Art Symposium 2010
September 24-25, 2010
Chicago, United States

Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
September 24-26, 2010
San Juan, Puerto Rico

Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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