Volume 1.28 | Jul 27

Hematopoiesis News 1.28, July 27, 2010.  
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CD4+CD25+ Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation  ShareThis
In the setting of donor lymphocyte infusion after hematopoietic stem cell transplantation, researchers postulated that regulatory T cell depletion could improve alloreactivity and likewise the graft-versus-tumor effect of donor T cells. [Science]

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UCLA Scientists Isolate the First Stages of Tissue Production from Human Embryonic Stem Cells
Scientists have described a population of cells that mark the very first stage of differentiation of human embryonic stem cells as they enter a developmental pathway that leads to the production of blood, heart muscle, blood vessels and bone. [Press release from the UCLA Broad Stem Cell Research Center discussing online prepublication in Proceedings of the National Academy of Sciences United States of America]

La Jolla Institute Teams with Dana-Farber and Washington University on Sickle Cell Clinical Trial
Researchers from the La Jolla Institute for Allergy & Immunology have joined forces with the Dana-Farber Cancer Institute in Boston and Washington University in St. Louis to investigate a potential new therapy for sickle cell disease, a severe and chronic illness affecting more than 70,000 Americans and several million people worldwide. [La Jolla Institute Press Release]

Discovery Suggests Possible Treatment Strategy for Aggressive Leukemias 
Researchers have identified a protein called Musashi that prevents cells from maturing, creating a large population of immature cells, which is one of the hallmarks of chronic myelogenous leukemia. [Press release from Duke University Medical Center discussing online prepublication in Nature]

Gene Therapy Benefits Persist in SCID
Gene therapy appears to have long-term success for treating X-linked severe combined immunodeficiency disease (SCID) – but recipients are at risk for acute leukemia, according to a small study from France. [Press release from MedPage Today discussing online prepublication in The New England Journal of Medicine]

Amazing Moles
Researchers have made the first identification of a new type of adaptation in the blood of moles which allows more efficient transport of carbon dioxide. [Press release from the University of Manitoba discussing online prepublication in BMC Evolutionary Biology]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)


Regulation of Myeloid Leukemia by the Cell-Fate Determinant Musashi
Here, researchers have used mouse models of chronic myelogenous leukemia to show that disease progression is regulated by the Musashi-Numb signalling axis. [Nature]

MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1
Researchers examined the role of the p53-induced microRNA miR-34a in hematopoiesis by gain-of-function analysis in murine bone marrow. [Immunity]

Multicenter Survey on the Outcome of Transplantation of Hematopoietic Cells in Patients with the Complete Form of DiGeorge Anomaly
Seventeen patients transplanted with hematopoietic cells to correct severe T lymphocyte immunodeficiency due to complete DiGeorge anomaly were identified worldwide and retrospective data were obtained using a questionnaire-based survey. [Blood]

RH Genotyping in a Sickle Cell Disease Patient Contributing to Hematopoietic Stem Cell Transplantation Donor Selection and Management
This case documents that blood unit selection should be based on genotype rather than one matching haplotype. [Blood]

Mapping the First Stages of Mesoderm Commitment During Differentiation of Human Embryonic Stem Cells
Researchers report that mesoderm commitment from human embryonic stem cells is initiated by epithelial-to-mesenchymal transition as shown by gene expression profiling and by reciprocal changes in expression of the cell surface proteins, EpCAM/CD326 and NCAM/CD56. [Proc Natl Acad Sci U S A]

Molecular Basis of a Novel Adaptation to Hypoxic-Hypercapnia in a Strictly Fossorial Mole
Here, researchers report that strictly fossorial eastern moles (Scalopus aquaticus ) have evolved a low O2 affinity, DPG-insensitive hemoglobin – contrary to expectations for a mammalian species that is adapted to the chronic hypoxia and hypercapnia of subterranean burrow systems. [BMC Evol Biol]

Three-Dimensional Culture of Mouse Bone Marrow Cells Within a Porous Polymer Scaffold: Effects of Oxygen Concentration and Stromal Layer on Expansion of Hematopoietic Progenitor Cells
To establish an ex vivo expansion method of hematopoietic progenitor cells (HPCs) and erythroid cells, three-dimensional cultures of mouse bone marrow cells were performed, employing a porous polyvinyl formal resin as a scaffold. [J Tissue Eng Regen Med]

CD4+CD25+ Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation
In the setting of donor lymphocyte infusion after hematopoietic stem cell transplantation, researchers postulated that regulatory T cell depletion could improve alloreactivity and likewise the graft-versus-tumor effect of donor T cells. [Sci Transl Med]


Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency
Researchers reviewed long-term outcomes after gene therapy in nine patients with X-linked severe combined immunodeficiency (SCID-X1), which is characterized by the absence of the cytokine receptor common gamma chain. [N Engl J Med]


Thermogenesis Announces Preliminary Fourth Quarter 2010 Financial Results; Revenues Expected to Exceed $7 Million
ThermoGenesis Corp. says it expects revenues for the quarter ended June 30, 2010, to be approximately $7.3 million and to report a small net loss for the quarter, in the range of $150,000 to $450,000, subject to final audit adjustments. [ThermoGenesis Corp. Press Release]

Cubist Pharmaceuticals to Ring the NASDAQ Stock Market Opening Bell
Cubist Pharmaceuticals, Inc., a leading acute care therapeutics company, announced that its President and CEO Michael Bonney will preside over the NASDAQ Opening Bell on Tuesday, July 20, 2010 at 9:30 a.m. [Cubist Pharmaceuticals, Inc. Press Release]

Six Researchers to Receive Prestigious Awards From the American Society of Hematology
The American Society of Hematology (ASH), the world’s largest professional society of blood specialists, will honor six scientists who have made significant contributions to the understanding and treatment of hematologic diseases. [The American Society of Hematology Press Release]


NIH Asks for Input on Closing Loophole in Conflict-of-Interest Rule
Responding to yet another flap about the influence of drug companies on biomedical research, the National Institutes of Health (NIH) has decided it needs more time to revise its rules for policing conflicts of interest so that sanctions will move with an investigator if he or she changes institutions. [National Institutes of Health, United States]

NIH Director Announces Appointment of Alan Guttmacher as Director of NICHD
National Institutes of Health Director Francis S. Collins M.D., Ph.D., announced today the appointment of Alan E. Guttmacher, M.D., as director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [National Institutes of Health, United States]

Office of Biotechnology Activities; Recombinant DNA Research: Proposed Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines) (Doc. 2010-17668) [National Institutes of Health, United States]

National Institute of General Medical Sciences; Notice of Closed Meeting (Doc. 2010-18088) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (Doc. 2010-18052) [National Institutes of Health, United States]

FDA and Other Federal Agencies Collaborate to Improve Chemical Screening [Food and Drug Administration, United States]

Gene-Testing Companies May Need U.S. Regulators Review, FDA Letters Say [Food and Drug Administration, United States]

Novartis Pharmaceuticals Corp. et al.; Withdrawal of Approval of 27 New Drug Applications and 58 Abbreviated New Drug Applications (Docket No. FDA-2010-N-0318) [Food and Drug Administration, United States]

International Conference on Harmonization; Draft Guidance on Q4B Evaluation and Recommendation of Pharmacopoeial Texts for Use in the  International Conference on Harmonization Regions; Annex 13 on Bulk  Density and Tapped Density of Powders General Chapter; Availability;  Correction (Docket No. FDA-2010-D-0347) [Food and Drug Administration, United States]

EVENTS (Listed by Date)

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
September 21-24, 2010
Washington D.C., United States

American Society of Hematology (ASH) State-of-the-Art Symposium 2010
September 24-25, 2010
Chicago, United States

Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
September 24-26, 2010
San Juan, Puerto Rico

Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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