Volume 1.17 | May 11

Hematopoiesis News 1.17, May 11, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


The Inositol Phosphatase SHIP-1 is Negatively Regulated by Fli-1 and its Loss Accelerates Leukemogenesis
In this study, researchers have shown that F-MuLV-infected SHIP-1 knockout mice display accelerated erythroleukemia progression. [Blood]

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Drinking While Pregnant Tied to Rare Leukemia in Offspring
Pregnant woman may have another reason to avoid drinking, with a new study finding that alcohol use during pregnancy ups the risk for a rare blood cancer in children. [Press release from Yahoo! discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention]

Leukaemia Busters Scientists Make Research Breakthrough
Scientists working in The Simon Flavell Leukaemia Research Laboratory at Southampton General Hospital have made a breakthrough discovery on how to increase the potency of immunotoxin treatment by over one million-fold for certain types of leukemia and lymphoma. [Leukaemia Busters Press Release]

Anemia Drugs Hold Dangers for Kidney Patients
The powerful drugs used to fight anemia caused by kidney failure increase the risk for cardiovascular problems such as heart attack, a major study has found. [Press release from Bloomberg Businessweek discussing online prepublication in Annals of Internal Medicine]

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Live Imaging of Runx1 Expression in the Dorsal Aorta Tracks the Emergence of Blood Progenitors from Endothelial Cells
By time-lapse microscopy of Runx1-enhanced green fluorescent protein transgenic zebrafish embryos, researchers were able to capture a subset of cells within the ventral endothelium of the dorsal aorta, as they acquire hemogenic properties, and directly emerge as presumptive hematopoietic stem cells. [Blood]

Opposing Roles of Polycomb Repressive Complexes in Hematopoietic Stem and Progenitor Cells
Researchers have investigated the role of polycomb repressive complexes in hematopoietic stem cells and progenitor populations. [Blood]

Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate
The analysis not only reveals new insights into hematopoietic stem cell regulatory network functionality but also provides a novel and widely applicable strategy to incorporate experimental measurements into dynamical network models. [PLoS Comput Biol]

Expression of a Src-Family Kinase in CML Cells Induces Resistance to Imatinib in a Kinase-Dependent Manner
Here researchers tested whether Hck overexpression is sufficient to induce imatinib resistance using both wild-type Hck and a mutant (Hck-T338A) that is uniquely sensitive to the pyrazolo-pyrimidine inhibitor, NaPP1. [J Biol Chem]

Protein Arginine Methyltransferase 1 Suppresses Megakaryocytic Differentiation Via Modulation of the p38 Mitogen-Activated Protein Kinase Pathway in K562 Cells
Researchers propose modulation of the p38 MAP kinase pathway by protein arginine methyltransferase 1 as a novel mechanism regulating megakaryocytic differentiation. This study thus provides a new perspective on the promotion of megakaryopoiesis. [J Biol Chem]


Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12
This cytogenetic study of 729 childhood patients classified them into 22 subgroups and evaluated their incidence and risk of childhood acute myeloid leukemia. [J Clin Oncol]

Deletions of the Derivative Chromosome 9 Do Not Influence the Response and the Outcome of Chronic Myeloid Leukemia in Early Chronic Phase Treated With Imatinib Mesylate: GIMEMA CML Working Party Analysis
To investigate the prognostic value of der(9) deletions in early chronic-phase chronic myeloid leukemia (CML), researchers performed an analysis of three prospective imatinib trials of the Italian Group for Hematological Malignancies of the Adult (GIMEMA) CML Working Party. [J Clin Oncol]

A Novel Prognostic Model in Elderly Patients with Acute Myeloid Leukemia – Results of 909 Patients Entered into the Prospective AML96 Trial
Researchers present an analysis of potential prognostic factors derived from a large multicenter trial performed in patients with acute myeloid leukemia older than 60 years. [Blood]

Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study
This study aimed to identify subgroups of childhood cancer survivors at highest risk of consuming alcohol, consuming above recommended weekly levels, and consuming potentially harmful amounts and compare survivor risks with those expected from the general population. [Cancer Epidemiol Biomarkers Prev]


Glaxo’s ‘Red Wine’ Drug Trial Halted Over Safety Concerns
In a possible setback for scientists attempting to make drugs out of a substance found in red wine, GlaxoSmithKline PLC said a clinical trial of one drug in cancer patients has been halted due to safety concerns. [The Wall Street Journal]

S*BIO and Onyx Pharmaceuticals Announce Expanded Development Collaboration for JAK2 Inhibitors
S*BIO Pte Ltd and Onyx Pharmaceuticals, Inc. announced the expansion of their development collaboration and option and license commercialization agreement for S*BIO’s novel JAK2 inhibitors, SB1518 and SB1578, also known as ONX 0803 and ONX 0805, respectively. [Onyx Pharmaceuticals, Inc. Press Release]


NIH Starts to Flesh out Drug Development Program
Lawmakers began discussing the details of a newly created drug development program at the National Institutes of Health (NIH). NIH Director Francis Collins told a Senate panel that he’s eager to get started-once the program has a budget. [National Institutes of Health, United States]

Notice of Funding Opportunity for a Cell Characterization Core for the National Heart, Lung and Blood Institute Progenitor Cell Biology Consortium (NOT-HL-10-109) [National Institutes of Health, United States]

Notice of Intent to Publish Request for Applications for the Blood and Marrow Transplant Clinical Trials Network Data Coordinating Center (U10) (NOT-HL-10-108) [National Institutes of Health, United States]

Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]

Request for Information: Scientific and Regulatory Issues to be Explored at an Upcoming Pluripotent Stem Cell Workshop Involving NIH and FDA (NOT-NS-10-016) [National Institutes of Health, United States]

Drug Safety and Risk Management Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes (Docket No. FDA-2010-N-0184) [Food and Drug Administration, United States]


Stem Cells, Tissue Homeostasis and Cancer Conference
May 12-15, 2010
Heidelberg, Germany

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Systems Biology of Stem Cells
May 24-25, 2010
Irvine, United States

International Symposium, Stem Cells in Biology and Disease
May 26-28, 2010
Lisbon, Portugal

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

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