Volume 1.15 | Apr 27

Hematopoiesis News 1.15, April 27, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Knockdown of N-Cadherin Suppresses the Long-Term Engraftment of Hematopoietic Stem Cells
Here, researchers analyzed the function of N-cadherin in the regulation of the proliferation and long-term repopulation activity of hematopoietic stem/progenitor cells by the transduction of N-cadherin shRNA. [Blood]

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New Microscopy Technique Reveals Mechanics of Blood Cell Membranes
Researchers developed a model that could lead to breakthroughs in screening and treatment of blood-cell-morphology diseases, such as malaria and sickle-cell disease. [Press release from the University of Illinois discussing online prepublication in Proceedings of the National Academy of Sciences U S A]




Ferrochelatase Forms an Oligomeric Complex with Mitoferrin-1 and Abcb10 for Erythroid Heme Biosynthesis
Researchers have derived stable Friend mouse erythroleukemia cell clones expressing either Mfrn1-FLAG or Abcb10-FLAG and by affinity purification and mass spectrometry have identified ferrochelatase as an interacting protein for both Mfrn1 and Abcb10. [Blood]

Measurement of Red Blood Cell Mechanics During Morphological Changes
Here researchers apply a noncontact optical interferometric technique to quantify the thermal fluctuations of red blood cell membranes with 3 nm accuracy over a broad range of spatial and temporal frequencies. [Proc Natl Acad Sci U S A]

Successful Treatment of Metachromatic Leukodystrophy Using Bone Marrow Transplantation of HoxB4 Overexpressing Cells
To evaluate the contribution of bone marrow (BM) cells to treat neurological disorders, researchers examined the effectiveness of BM cells expressing the homeobox B4 (HoxB4) gene to cure mice with metachromatic leukodystrophy through transplantation. [Leukemia]

Transcriptional Silencing of Ets-1 Oncogene Contributes to Human Granulocytic Differentiation
This study focused on the role of Ets-1 during granulocytic differentiation of NB4 promyelocytic and HL60 myeloblastic leukemia cell lines induced by all-trans retinoic acid. [Haematologica]

Additive and Global Functions of HoxA Cluster Genes in Mesoderm Derivatives
Researchers report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display a striking effect in the hematopoietic system, which involves hematopoietic stem cells as well as the erythroid lineage, indicating that several Hoxa genes are necessary for normal hematopoiesis to occur. [Dev Biol]

CD13 is Dispensable for Normal Hematopoiesis and Myeloid Cell Functions in the Mouse
Althrough CD13 is highly expressed on myeloid cells and is a reliable marker of the myeloid lineage of normal and leukemic cells, it is not a critical regulator of hematopoietic development, hemostasis, or myeloid cell function. [J Leukoc Biol]


Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia
Allogeneic hematopoietic cell transplantation (HCT) after high-dose conditioning regimens imposes prohibitively high risks of morbidity and mortality for patients with high-risk acute myeloid leukemia who are older or have comorbid conditions. Here, researchers examined outcomes after nonmyeloablative allogeneic HCT in such patients. [J Clin Oncol]

Rituximab Maintenance Treatment of Relapsed/Resistant Follicular Non-Hodgkin’s Lymphoma: Long-Term Outcome of the EORTC 20981 Phase III Randomized Intergroup Study
In 2006, researchers published the results of the European Organisation for Research and Treatment of Cancer phase III trial EORTC 20981 on the role of rituximab in remission induction and maintenance treatment of relapsed/resistant follicular lymphoma. Now, they report the long-term outcome of maintenance treatment, with a median follow-up of 6 years. [J Clin Oncol]

Phase II and Pharmacodynamic Study of Oral Forodesine in Patients with Advanced and/or Fludarabine-Treated Chronic Lymphocytic Leukemia
Forodesine is a new and potent purine nucleoside phosphorylase inhibitor. Chronic lymphocytic leukemia patients with primary resistance to fludarabine-based therapy or with progressive disease were eligible for oral forodesine (200mg/day) for up-to 24 weeks. [Blood]


Hana Biosciences Completes Pre-NDA Meeting With FDA for Marqibo in Adult Acute Lymphoblastic Leukemia
Hana Biosciences announced that the Company has completed a pre-New Drug Application meeting with the U.S. Food and Drug Administration related to its lead product candidate, Marqibo for the treatment of relapsed/refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia. [Hana Biosciences Inc. Press Release]

Gen-Probe Reports Financial Results for the First Quarter of 2010
Gen-Probe Incorporated reported financial results for the first quarter of 2010, highlighted by $135.4 million of total revenues and earnings per share of $0.48 on both a non-GAAP and GAAP basis. [Gen-Probe Inc. Press Release]

Chronic Fatigue Link Prompts Blood Ban
Australia’s Red Cross Blood Service has placed a two-year moratorium on accepting blood donations from people who have ever had chronic fatigue syndrome. [The Sidney Morning Herald]


Science Panel Cuts Authorization Levels for Three COMPETES Agencies
The House of Representatives Science and Technology Committee scaled back proposed funding levels for three key science agencies as part of its reauthorization of the America COMPETES Act. [The House of Representatives Science and Technology Committee, United States]

Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants
The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commissioner, European Union]

Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092) [National Institutes of Health, United States]

Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 { NOT-AR-10-035) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States]

Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States]

Guidance for Industry: Requalification Method for Reentry of Blood Donors Deferred Because of Reactive Test Results for Antibody to Hepatitis B Core Antigen (Anti-HBc); Availability (Docket No. FDA-2008-D-0263) [Food and Drug Administration, United States]

Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety and Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]


Stem Cells, Tissue Homeostasis and Cancer Conference
May 12-15, 2010
Heidelberg, Germany

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Systems Biology of Stem Cells
May 24-25, 2010
Irvine, United States

International Symposium, Stem Cells in Biology and Disease
May 26-28, 2010
Lisbon, Portugal

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

The European Molecular Biology Organization (EMBO) Meeting 2010
September 4-7, 2010
Barcelona, Spain

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

Stem Cells and Regeneration
October 3-9, 2010
Woods Hole, United States

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

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