Volume 1.14 | Apr 20

Hematopoiesis News 1.14, April 20, 2010.  
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

New Class of Drug Kills Lymphoma Cells
Researchers have designed a new class of drugs that target BCL6, a master regulatory protein responsible for causing the most common type of non-Hodgkin’s lymphoma. [Press release from Weill Cornell Medical College discussing online prepublication in Cancer Cell]

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SCIENCE NEWS

CombinatoRx Discovers Novel Multi-Target Mechanism for the Treatment of Hematologic Malignancies
CombinatoRx researchers, in collaboration with the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, demonstrate the powerful and unexpected synergistic interactions of A2A Agonist and PDE Inhibitors as potential adjunctive therapy to glucocorticoid containing regimens in the treatment of multiple myeloma and other B-cell malignancies. [Press release from CombinatoRx, Inc. discussing online prepublication in Blood]

Human Development Index Linked to Stem Cell Transplant Rates and Success in Leukemia Patients
A new study reports that in Europe, socioeconomic factors have a direct correlation to the rates and outcomes of stem cell transplantation for patients with acute myeloid leukemia. [Press release from EurekAlert! discussing online prepublication in Blood]

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CURRENT PUBLICATIONS

LABORATORY RESEARCH 

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo
Researchers combined computer-aided drug design with functional assays to identify low-molecular-weight compounds that bind to the corepressor binding groove of the BCL6 BTB domain. [Cancer Cell]

Sp1/NF(Kappa)B/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia

Here, researchers show that KIT mutations lead to MYC -dependent miR-29b repression and increased levels of the miR-29b target Sp1 in KIT-driven leukemia. [Cancer Cell]

Tel1/ETV6 Specifies Blood Stem Cells through the Agency of VEGF Signaling
Researchers show that the leukemia-associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells in the dorsal aorta. [Dev Cell]

Adenosine A2A Receptor Agonists and PDE Inhibitors: A Synergistic Multi-Target Mechanism Discovered Through Systematic Combination Screening in B-Cell Malignancies
Researchers discovered an unexpected synergistic interaction between adenosine receptor agonists and phosphodiesterase inhibitiors that displays substantial activity in a panel of multiple myeloma (MM) and diffuse large B cell lymphoma cell lines and tumor cells from MM patients. [Blood]

Elevated IL-17 Produced by TH17 Cells Promotes Myeloma Cell Growth and Inhibits Immune Function in Multiple Myeloma
As IL-6 and TGF-beta are important for the generation of TH17 cells, researchers observed a significantly elevated baseline and induced frequency of TH17 cells in peripheral blood and bone marrow mononuclear cells from multiple myeloma patients compared to healthy donors. [Blood]

Positioning of Bone Marrow Hematopoietic and Stromal Cells Relative to Blood Flow In Vivo : Serially Reconstituting Hematopoietic Stem Cells Reside in Distinct Non-Perfused Niches
Researchers report that the position of phenotypic hematopoietic stem cells, multipotent and myeloid progenitors relative to blood flow, follows a hierarchy reflecting differentiation stage whereas mesenchymal stem cells are perivascular. [Blood]

Array-Based Genomic Resequencing of Human Leukemia
To identify oncogenes in leukemias, researchers performed large-scale resequencing of the leukemia genome using DNA sequence arrays that determine approximately 9 Mbp of sequence corresponding to the exons or exon-intron boundaries of 5648 protein-coding genes. [Oncogene]

CLINICAL RESEARCH

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group
The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional categories of myeloid and lymphoid malignancies. [J Clin Oncol]

Anemia in Hodgkin’s Lymphoma: The Role of Interleukin-6 and Hepcidin
Cytokines play a pivotal role in Hodgkin’s lymphoma (HL). Because interleukin-6 induces expression of hepcidin, one of the principal regulators of iron metabolism, researchers studied the contribution of hepcidin in anemia in HL at diagnosis. [J Clin Oncol]

Vaccination With Synthetic Analog Peptides Derived from WT1 Oncoprotein Induces T Cell Responses in Patients with Complete Remission from Acute Myeloid Leukemia
A pilot study was undertaken to assess the safety, activity and immunogenicity of a polyvalent WT1 peptide vaccine in patients with acute myeloid leukemia in complete remission but with molecular evidence of WT1 transcript. [Blood]

Long-Term Outcomes After Hematopoietic SCT for Adult T Cell Leukemia/Lymphoma: Results of Prospective Trials
This is the first report to clarify the long-term outcomes after a reduced-intensity conditioning regimen for adult T cell leukemia/lymphoma patients. [Bone Marrow Transplant]

INDUSTRY NEWS

The University of Texas Health Science Center at Houston Stem Cell Scientists Explore Treatments for Blood Disorders and Lung Diseases
Stem cell scientists were awarded stimulus grants totaling almost $2 million to research experimental treatments for blood disorders and inherited lung diseases affecting children. [The University of Texas Health Science Center at Houston Press Release]

$2.3 Million in New NIH Funding Extends Cancer Research Projects at Cincinnati Children’s
Two scientific teams at Cincinnati Children’s Hospital Medical Center are receiving a total of $2.3 million in research funding from the National Institutes of Health to continue promising studies seeking novel treatments for leukemia and bone marrow failure. [Cincinnati Children’s Hospital Medical Center Press Release]

Einstein Receives $10 Million National Institutes of Health Grant to Expand Stem Cell Research Facilities
Albert Einstein College of Medicine of Yeshiva University has been awarded $10 million from the National Institutes of Health to expand its stem cell research capabilities. [Albert Einstein College of Medicine Press Release]

Apollo Hospitals Group Forays into Stem Cell Research
Apollo Hospitals Educational and Research Centre has set up Cell and Molecular Biology Research Center, which will be involved in stem cell research and clinical trials, in its Jubilee Hills campus. [Apollo Hospitals Group Press Release]

Stem Cell, Bone Marrow Transplants Increasingly Easy, Common
Donating blood stem cells or bone marrow to assist patients fighting blood or immune disorders has never been easier, or more popular. [The Columbian]


POLICY NEWS

Stem Cell Funding in Sight
Two of the most widely used embryonic stem cell lines could be just weeks away from being eligible for United States federal funding. [Obama Administration, United States]

Patents Block Competition, Slow Innovation in Gene Testing
Exclusive licenses to gene patents, most of which are held by academic institutions and based on taxpayer-funded research, do more to block competition in the gene testing market than to spur the development of new technologies for gauging disease risk. [Duke University Press Release]

Policy Reminder Concerning Appendix Materials for All National Institutes of Health/Agency for Healthcare Research and Quality/National Institute for Occupational Safety and Health Grant Applications (NOT-OD-10-077) [National Institutes of Health, United States]

Enhancing Peer Review: Clarification of Resubmission Policy and Determination of New Application Status (NOT-OD-10-080) [National Institutes of Health, United States]

Guidance on Confirming Appropriate Charges to NIH Awards During Periods of Noncompliance for Activities Involving Animals (NOT-OD-10-081) [National Institutes of Health, United States]

Update of Sample Animal Welfare Assurance for Foreign Institutions (NOT-OD-10-083) [National Institutes of Health, United States]

Agency for Healthcare Research and Quality Small Research Grant Program (R03) (PAR-10-168) [National Institutes of Health, United States]

EVENTS

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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