Volume 1.02 | Jan 26

A Variant of the Gene Growth Factor Independence 1 (GFI1) Predisposes to a Subtype of Blood Cancer
A large international research group has discovered that a variant of the gene GFI1 predisposes humans to develop acute myeloid leukemia. [Institut de Recherches Cliniques de Montréal, Montréal]

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LABORATORY RESEARCH

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
Lmo2 promotes the self-renewal of preleukemic thymocytes, providing a mechanism by which committed T cells can then accumulate additional genetic mutations required for leukemic transformation. [Science]

Transferrin Therapy Ameliorates Disease in Beta-Thalassemic Mice
Results indicate that transferrin is a limiting factor contributing to anemia in these mice and suggest that transferrin therapy might be beneficial in human beta-thalassemia. [Nat Med]

Knockdown of Fanconi Anemia Genes in Human Embryonic Stem Cells Reveals Early Developmental Defects in the Hematopoietic Lineage
Researchers have created a human-specific in vitro system to study early hematopoietic development in Fanconi anemia using a lentiviral RNAi strategy in human embryonic stem cells. [Blood]

Investigation of Murine Spleen as a Niche for Hematopoiesis
Evidence for the maintenance of donor-type myeloid cells after 2 to 4 weeks reflected development from hematopoietic progenitors endogenous to spleen. Overall, this study adds further evidence that spleen can support endogenous myelopoiesis. [Transplantation]

FOG-1-Mediated Recruitment of NuRD is Required for Cell Lineage Re-Enforcement During Hematopoiesis
To test the importance of transcriptional co-factor Friend of GATA1 (FOG-1)/nucleosome remodelling and histone deacetylase (NuRD) interaction for hematopoiesis in vivo, researchers generated mice with a mutation that specifically disrupts FOG-1/NuRD interaction. [EMBO J]

Cyclin C Regulates Human Hematopoietic Stem/Progenitor Cell Quiescence
Researchers have identified an important role of cyclin C (CCNC) in regulating human hematopoietic stem/progenitor cell quiescence, as knocking down CCNC expression in human cord blood CD34+ cells resulted in a significant increase in quiescent cells that maintain CD34 expression. [Stem Cells]

Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells
This study compared the gene expression profiles of steady-state bone marrow hematopoietic stem cells (HSCs) to non-self-renewing multipotent progenitors; to HSC treated with mobilizing drugs that expand the HSC pool and induce egress from the marrow; and to leukemic HSC in a mouse model of chronic myelogenous leukemia. [PLoS ONE]

Extrinsic Signals Determine Myeloid-Erythroid Lineage Switch in MN1 Leukemia
To test whether the microenvironment impacts on leukemic phenotype, researchers exploited the MN1 model of acute myeloid leukemia under defined genetically-modified microenvironmental conditions. [Exp Hematol]

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2010 Bone Marrow Transplant Tandem Meetings
February 24-28, 2010
Orlando, United States

36th Annual Meeting of the European Group for Blood & Marrow Transplantation
March 21-24, 2010
Vienna, Austria

12th Biennial CBMTG Conference
April 7-10, 2010
Vancouver, Canada

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the ISBT in joint cooperation with the 43rd Congress of the DGTI
June 26-July 1, 2010
Berlin, Germany

ISEH 2010 Meeting
September 15-18, 2010
Melbourne, Australia

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